FB2026_03 , released September 17, 2026
Allele: Dmel\p38aDN.UAS
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General Information
Symbol
Dmel\p38aDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0263922
Feature type
allele
Associated gene
Dmel\p38a
Associated Insertion(s)
Carried in Construct
P{UAS-p38a.DN}
Also Known As
UAS-Dp38a-DN
Key Links
Transgenic product class
dominant_negative_variant
(Sekine et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Sekine et al., 2011)
Mutagen
in vitro construct
(Sekine et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-p38a.DN}
Cytology
Description

UAS drives expression of a dominant-negative version of p38a.

(Sekine et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
p38a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of p38aDN.Scer\UAS partially suppresses the melanisation of the thorax seen in adults expressing Dhx15GS11266 under the control of Scer\GAL4pnr-MD237.

      (Mosallanejad et al., 2014)

      Co-expression of Mpk2DN.Scer\UAS partially suppresses the melanisation of the adult thorax cuticle seen in flies expressing slimGS10238 under the control of Scer\GAL4pnr-MD237.

      (Sekine et al., 2012)

      Co-expression of Mpk2DN.Scer\UAS abolishes the thorax pigmentation defects seen in Pk92BΔN.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4pnr-MD237 flies.

      (Sekine et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mpk2DN.Scer\UAS
      p38aDN.Scer\UAS
      p38aDN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)