FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\daΔex1.UAS
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General Information
Symbol
Dmel\daΔex1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0282378
Feature type
allele
Associated gene
Dmel\da
Associated Insertion(s)
Carried in Construct
P{UAS-da.ex1}
Key Links
Transgenic product class
inframe_deletion
(Bhattacharya and Baker, 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Bhattacharya and Baker, 2011)
Mutagen
in vitro construct
(Bhattacharya and Baker, 2011)
Progenitor genotype
Carried in construct
P{UAS-da.ex1}
Cytology
Description

UAS regulatory sequences drive expression of da coding sequences lacking the non-coding first exon.

(Bhattacharya and Baker, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
da
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of daΔex1.Scer\UAS in mutant eye clones (under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C) results in poor clone growth, with these clones being rarely found anterior to the morphogenetic furrow. Their recovery is enhanced in a M/+ background. These clones show some ectopic neuronal differentiation and can accelerate the progression of the furrow.

      Ectopic expression of daΔex1.Scer\UAS anterior to the morphogenetic furrow, under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C leads to neuronal differentiation by 14% of the cells.

      (Bhattacharya and Baker, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Approximately 81% of cells overexpressing both atoScer\UAS.cJa and daΔex1.Scer\UAS ahead of the morphogenetic furrow (under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C) differentiate into neurons.

      (Bhattacharya and Baker, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      daΔex1.Scer\UAS
      daΔex1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)