FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DnaJ-1ΔJ.UAS.Tag:FLAG
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General Information
Symbol
Dmel\DnaJ-1ΔJ.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0282996
Feature type
allele
Associated gene
Dmel\DnaJ-1
Associated Insertion(s)
Carried in Construct
P{UAS-DnaJ-1.ΔJ.FLAG}
Key Links
Transgenic product class
inframe_deletion
(Chan et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chan et al., 2000)
Mutagen
in vitro construct
(Chan et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-DnaJ-1.ΔJ.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of DnaJ-1 lacking the J domain (amino acids 1-77 are deleted), which is tagged at the C-terminal end with Tag:FLAG.

(Chan et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
DnaJ-1
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurodegenerative disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Chan et al., 2000)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of DnaJ-1ΔJ.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4lz-gal4 does not significantly affect the number or size of third instar larval circulating crystal cells.

      (Miller et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of DnaJ-1ΔJ.Scer\UAS.T:Zzzz\FLAG enhances the weak eye phenotype seen in flies that weakly express Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU, such that loss of pigmentation and collapse of the eye is seen.

      Flies that co-express Hsap\HSPA1LScer\UAS.cWa, Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 and DnaJ-1ΔJ.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PU have normal eyes.

      (Chan et al., 2000)
      Complementation and Rescue Data
      Fails to rescue

      DnaJ-1ΔJ.UAS.Tag:FLAG/Scer\GAL4lz-gal4 fails to rescue DnaJ-1C/DnaJ-1A

      (Miller et al., 2017)
      Comments

      The expression of DnaJ-1ΔJ.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4lz-gal4 fails to rescue the increased number and size of circulating crystal cells present in DnaJ-1A/DnaJ-1C transheterozygous third instar larvae.

      (Miller et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DnaJ-1ΔJ.Scer\UAS.T:Zzzz\FLAG
      DnaJ-1ΔJ.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)