FlyBase Allele Report: Dmel\Bace[5243]

General Information

Symbol

Dmel\Bace⁵²⁴³

Species

D. melanogaster

Name

FlyBase ID

FBal0283017

Feature type

allele

Associated gene

Dmel\Bace

Associated Insertion(s)

Carried in Construct

Also Known As

dBACE⁵²⁴³

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: P190L.

(Bolkan et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Bace²⁰⁴⁵)

(Bolkan et al., 2012)

abnormal neuroanatomy | adult stage (with Bace²⁵²⁵)

(Bolkan et al., 2012)

lethal (with Df(2L)Exel7038)

(Bolkan et al., 2012)

lethal (with Df(2L)N22-14)

(Bolkan et al., 2012)

Phenotype Manifest In

adult brain (with Bace²⁰⁴⁵)

(Bolkan et al., 2012)

cell body rind of adult lamina (with Bace²⁰⁴⁵)

(Bolkan et al., 2012)

cell body rind of adult lamina (with Bace²⁵²⁵)

(Bolkan et al., 2012)

lamina (with Bace²⁰⁴⁵)

(Bolkan et al., 2012)

Detailed Description

Statement

Reference

28 day old Bace²⁵²⁵/Bace⁵²⁴³ flies show degeneration of the lamina, with vacuolisation in the lamina cortex.

28 day old Bace²⁰⁴⁵/Bace⁵²⁴³ flies show degeneration of the lamina, with vacuolisation in the lamina cortex. The flies also show vacuoles in the lamina neuropil and central brain.

(Bolkan et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Bace⁵²⁴³/Bace[+] is a suppressor of abnormal phototaxis | adult stage | progressive phenotype of Appl^UAS.cCSa, Scer\GAL4^elav.PU

(Bolkan et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The age-dependent decline in performance index in a fast phototaxis assay of flies expressing Appl^{Scer\UAS.cCSa} under the control of Scer\GAL4^elav.PU is suppressed if they are also heterozygous for Bace⁵²⁴³. The flies also show an increase in survival.

(Bolkan et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Bace⁵²⁴³

dBACE⁵²⁴³

(Bolkan et al., 2012)

dBace⁵²⁴³

(Rieche et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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