FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aurAUbi-p63E.GFP
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General Information
Symbol
Dmel\aurAUbi-p63E.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0283117
Feature type
allele
Associated gene
Dmel\aurA
Associated Insertion(s)
Carried in Construct
P{Ubi-GFP-Aur-A}
Also Known As
Ubq-Aurora A-GFP
Key Links
Transgenic product class
wild_type
(Sabino et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sabino et al., 2011)
Mutagen
in vitro construct
(Sabino et al., 2011)
Progenitor genotype
Carried in construct
P{Ubi-GFP-Aur-A}
Cytology
Description

Ubi-p63E promoter sequences drive expression of aur coding sequences tagged at the N-terminal with Avic\GFP.

(Sabino et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
aurA
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aurUbi-p63E.T:Avic\GFP mutant neuroblasts exhibit completely disorganised mitotic spindles in 52% of cases.

      (Sabino et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      aurAUbi-p63E.GFP is an enhancer of abnormal mitotic cell cycle | somatic clone phenotype of jubE1

      (Sabino et al., 2011)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      aurAUbi-p63E.GFP is an enhancer of centrosome | somatic clone phenotype of jubE1

      (Sabino et al., 2011)

      aurAUbi-p63E.GFP is an enhancer of spindle | somatic clone phenotype of jubE1

      (Sabino et al., 2011)

      aurAUbi-p63E.GFP is an enhancer of neuroblast | somatic clone phenotype of jubE1

      (Sabino et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      jubE1 mutant neuroblasts expressing aurUbi-p63E.T:Avic\GFP exhibit mitotic spindle defects, with the proportion of disorganised spindles higher (61%) than that in jubE1 or aurUbi-p63E.T:Avic\GFP mutants alone. Mitosis in these double mutants is highly perturbed, as revealed by an increased mitotic index. These cells show severe mitotic abnormalities, such as aneuploidy, polyploidy and anaphases with lagging chromosomes. These more severe defects are not present in jubE1 mutants, where the mitotic index is not significantly different from that of wild-type.

      (Sabino et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      aurUbi-p63E.T:Avic\GFP
      aurAUbi-p63E.GFP
      aurAUbi-p63E.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (4)