FlyBase Allele Report: Dmel\Dop1R1[attP]

General Information

Symbol

Dmel\Dop1R1^attP

Species

D. melanogaster

Name

FlyBase ID

FBal0283278

Feature type

allele

Associated gene

Dmel\Dop1R1

Associated Insertion(s)

TI{TI}Dop1R1^attP

Carried in Construct

Also Known As

DopR1^attP

Key Links

Allele class

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

Mutagen

ends-out gene targeting

(Keleman et al., 2012)

Progenitor genotype

Associated Insertion(s)

TI{TI}Dop1R1^attP

Cytology

Description

The first coding exon of Dop1R1 has been deleted and replaced by a attP site and a single mFRT11 site.

(Keleman et al., 2012)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

mFRT11

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | male

(Keleman et al., 2012)

abnormal learning | male

(Keleman et al., 2012)

abnormal neurophysiology

(Cohn et al., 2015)

abnormal smell perception

(Cohn et al., 2015)

fertile

(Keleman et al., 2012)

viable

(Keleman et al., 2012)

Phenotype Manifest In

Detailed Description

Statement

Reference

Odor-evoked neurophysiology responses (measured by "sytGCaMP" fluorescence) across the gamma Kenyon cells is subtly abnormal in Dop1R1^attP mutants compared to controls.

(Cohn et al., 2015)

Homozygous naive males court at normal levels. However, the mutant males show a severe defect in courtship learning.

(Keleman et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Dop1R1^attP, Dop1R2^attP has abnormal neurophysiology phenotype

(Cohn et al., 2015)

Dop1R1^attP, Dop1R2^attP has abnormal smell perception phenotype

(Cohn et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Odor-evoked neurophysiology responses (measured by "sytGCaMP" fluorescence) across the gamma Kenyon cells is inverted in Dop1R2^attP/Dop1R1^attP mutants compared to controls.

(Cohn et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dop1R1^attP is rescued by Scer\GAL4^Tab2-201Y/Dop1R1^UAS.cKb

(Keleman et al., 2012)

Not rescued by

Dop1R1^attP is not rescued by Dop1R1^UAS.cKb/Scer\GAL4^c739

(Keleman et al., 2012)

Dop1R1^attP is not rescued by Scer\GAL4^c305a/Dop1R1^UAS.cKb

(Keleman et al., 2012)

Comments

Expression of DopR^Scer\UAS.cKb under the control of Scer\GAL4^Tab2-201Y fully rescues the courtship learning defects of DopR^attP males, while expression under the control of either Scer\GAL4^c739 or Scer\GAL4^c305a does not rescue the phenotype.

(Keleman et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Dop1R1^attP

Dop1R1^attp

(Chakravarti Dilley et al., 2020)

DopR1^attP

(Cohn et al., 2015, Keleman et al., 2012)

DopR1^attp

(Driscoll et al., 2021, Krüttner et al., 2015)

DopR^attP

Dopr1(attP)

(Dag et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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