FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bru1RRM2.UASp.mGFP6
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General Information
Symbol
Dmel\bru1RRM2.UASp.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0284048
Feature type
allele
Associated gene
Dmel\bru1
Associated Insertion(s)
Carried in Construct
P{UASp-bru1.RRM2.mGFP6}
Key Links
Transgenic product class
missense_variant
(Snee et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Snee et al., 2008)
Mutagen
in vitro construct
(Snee et al., 2008)
Progenitor genotype
bru1RRM2.UASp.mGFP6
(Snee et al., 2008)
Carried in construct
P{UASp-bru1.RRM2.mGFP6}
Cytology
Description

Two point mutations have been introduced into the RRM2 domain, resulting in K239A and F241A amino acid replacements.

(Snee et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
bru1
Tagged with
mGFP6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ovarian cysts expressing aretRRM2.Scer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 have the usual 16 germline cells, oogenesis proceeds to completion, the embryos are not noticeably smaller than normal, and the dorsal appendages appear wild type. However many embryos exhibit abdominal segmentation defects, having fewer than the usual 8 denticle belts.

      (Snee et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      aretRRM2.Scer\UAS.P\T.T:Avic\GFP-m6
      bru1RRM2.Scer\UAS.P\T.T:Avic\GFP-m6
      bru1RRM2.UASp.mGFP6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)