FB2026_02 , released June 18, 2026
Allele: Dmel\Abp1KO
Open Close
General Information
Symbol
Dmel\Abp1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0284218
Feature type
allele
Associated gene
Dmel\Abp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Koch et al., 2012)
Mutagen
FLPase
(Koch et al., 2012)
Progenitor genotype
PBac{WH}Abp1f05024
(Koch et al., 2012)
PBac{RB}Tgie01789
(Koch et al., 2012)
Cytology
Description

FLP-mediated recombination between the two progenitor insertions has deleted the genomic sequence between them, which includes the presumptive promoter region and part of the 5'UTR of Abp1.

(Koch et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:13,486,172..13,487,048 [-]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has deleted the sequence between them.

(Koch et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average speed of migration of Abp1KO/Df(3L)Exel6119 third instar larvae is only 74% of that of wild type.

      Homozygous and Abp1KO/Df(3L)Exel6119 third instar larvae have neuromuscular junction (NMJ) defects. The number of type Ib boutons per NMJ and the number of axonal branch points per NMJ are significantly reduced compared to controls.

      (Koch et al., 2014)

      Abp1KO/Df(3L)Exel6119 flies have kinked microchaetes, with the kinks almost always correlating with fusions of longitudinal ridges.

      Dorso-central macrochaetae have a large number of irregularly joined and fused ridges, resulting in an increased number of longitudinal ridges compared to wild type in Abp1KO/Df(3L)Exel6119 flies.

      (Koch et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Df(3L)Exel6119/Abp1KO is rescued by Scer\GAL4VGlut1-OK371/Abp1UAS.cKa

      (Koch et al., 2014)
      Partially rescued by

      Df(3L)Exel6119/Abp1KO is partially rescued by Abp1UAS.cKa/Scer\GAL4C57

      (Koch et al., 2014)

      Df(3L)Exel6119/Abp1KO is partially rescued by Scer\GAL4sca.PU/Abp1UAS.cKa

      (Koch et al., 2012)
      Comments

      The reduction in the number of type Ib boutons which is seen at the neuromuscular junction (NMJ) in Abp1KO/Df(3L)Exel6119 third instar larvae is rescued by expression of Abp1Scer\UAS.cKa under the control of Scer\GAL4VGlut-OK371 (in motorneurons), but not under the control of Scer\GAL4C57 (in muscles). The reduction in the number of axonal branch points per NMJ which is seen in Abp1KO/Df(3L)Exel6119 third instar larvae is rescued by expression of Abp1Scer\UAS.cKa under the control of either Scer\GAL4VGlut-OK371 or Scer\GAL4C57.

      (Koch et al., 2014)

      The extra longitudinal ridge phenotype seen in macrochaetae of Abp1KO/Df(3L)Exel6119 flies is partially rescued by expression of Abp1Scer\UAS.cKa under the control of Scer\GAL4sca.PU.

      (Koch et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Abp1KO
      abp1KO
      (Koch et al., 2014, Koch et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)