FB2026_02 , released June 18, 2026
Allele: Dmel\spartinUAS.Tag:HA
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General Information
Symbol
Dmel\spartinUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0284234
Feature type
allele
Associated gene
Dmel\spartin
Associated Insertion(s)
Carried in Construct
P{UAS-HA-spartin}
Key Links
Transgenic product class
wild_type
(Nahm et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Nahm et al., 2013)
Mutagen
in vitro construct
(Nahm et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-HA-spartin}
Cytology
Description

UAS regulatory sequences drive expression of spartin which is tagged with a Tag:HA epitope.

(Nahm et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
spartin
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 results in a significant decrease in bouton number and satellite bouton number at the neuromuscular junction in third instar larvae.

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 has no effect on the amplitude of the evoked excitatory junction current at the neuromuscular junction in third instar larvae.

      (Nahm et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of spartinScer\UAS.T:Ivir\HA1 slightly but significantly suppresses the increased vacuolisation in the brain seen in 20 day old flies expressing futschEP1419 under the control of Scer\GAL4elav-C155.

      (Nahm et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/spartinUAS.Tag:HA rescues spartin1/Df(3R)110

      (Nahm et al., 2013)
      Fails to rescue

      spartinUAS.Tag:HA/Scer\GAL4C57 fails to rescue spartin1/Df(3R)110

      (Nahm et al., 2013)
      Comments

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 rescues the increase in bouton number and satellite bouton number and the decrease in the amplitude of the evoked excitatory junction current seen at the neuromuscular junction in spartin1/Df(3R)110 third instar larvae. Expression under the control of Scer\GAL4C57 does not rescue these phenotypes.

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 rescues the impaired FM1-43FX dye uptake seen in the neuromuscular junctions of spartin1/Df(3R)110 third instar larvae.

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 rescues the reduced climbing ability of 20 day old spartin1/Df(3R)110 adults.

      Expression of spartinScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 rescues the show age-dependent neurodegeneration seen in spartin1/Df(3R)110 adults.

      (Nahm et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      spartinScer\UAS.T:Ivir\HA1
      spartinUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)