FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wgn22
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General Information
Symbol
Dmel\wgn22
Species
D. melanogaster
Name
FlyBase ID
FBal0284369
Feature type
allele
Associated gene
Dmel\wgn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Ruan et al., 2013)
Progenitor genotype
PBac{RB}wgne00637
(Ruan et al., 2013)
Cytology
Description

Scer\FRT-mediated recombination has produced a line in which the insertion is still present but deletion of approximately 1200bp of genomic sequence flanking the 5' end of the insertion has occurred.

(Ruan et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous third instar larvae have large gaps in the lamina with numerous abnormal thick axon bundles projecting into the medulla. Many mistargeted R2-R5 axons project into the medulla. This phenotype is 100% penetrant. The morphology of the R8 growth cones is abnormal.

      Homozygous R8 axon MARCM clones show severe targeting defects, failing to stay in their appropriate target zones and straying into neighbouring regions. Homozygous R2-R5 axon MARCM clones show appropriate targeting to the lamina region.

      (Ruan et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      wgn22 is partially rescued by Scer\GAL4elav.PU/wgnUAS.cRa.Tag:FLAG

      (Ruan et al., 2013)

      wgn22 is partially rescued by wgnUAS.cRa.Tag:FLAG/Scer\GAL4sca-109-68

      (Ruan et al., 2013)
      Comments

      Expression of wgnScer\UAS.cRa.T:Zzzz\FLAG under the control of Scer\GAL4elav.PU rescues the R2-R5 axon targeting defects seen in wgn22 hemizygotes in 37.5% of cases.

      Expression of wgnScer\UAS.cRa.T:Zzzz\FLAG under the control of Scer\GAL4sca-109-68 rescues the R2-R5 axon targeting defects seen in wgn22 hemizygotes in 66.7% of cases.

      (Ruan et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Wgn22
      (Chabu and Xu, 2014)
      wgn22
      (Trombley et al., 2023, Ruan et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)