FlyBase Allele Report: Dmel\hep[UAS.cUa]

General Information

Symbol

Dmel\hep^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0284406

Feature type

allele

Associated gene

Dmel\hep

Associated Insertion(s)

Carried in Construct

P{UAS-hep.U}

Also Known As

UAS-hep, UAS-hep^wt

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-hep.U}

Cytology

Description

UAS regulatory sequences drive expression of hep.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

hep

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration, with Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

Phenotype Manifest In

wing disc, with Scer\GAL4^ptc-559.1

(Rudrapatna et al., 2014)

Detailed Description

Statement

Reference

The epidermis of larvae expressing hep^UAS.cUa under the control of Scer\GAL4^A58 does not show wound closure defects.

(Lee et al., 2019)

Expression of hep^UAS.cUa under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

Neuronal expression of hep^Scer\UAS.cUa (under the control of Scer\GAL4^elav.PU) leads to glial cell specific lipid droplet accumulation.

Glial expression of hep^Scer\UAS.cUa (under the control of Scer\GAL4^54C) does not lead to lipid droplet accumulation.

(Liu et al., 2015)

Expression of hep^Scer\UAS.cUa in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4^ptc-559.1 results in cell migration.

(Rudrapatna et al., 2014)

Expression of hep^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF does not result in a small eye phenotype.

(Jones et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, hep^UAS.cUa has abnormal cell migration phenotype, suppressible by tsr[+]/tsr^N96A

(Rudrapatna et al., 2014)

Scer\GAL4^ptc-559.1, hep^UAS.cUa has abnormal cell migration phenotype, suppressible by ena²³/ena[+]

(Rudrapatna et al., 2014)

Scer\GAL4^ptc-559.1, hep^UAS.cUa has abnormal cell migration phenotype, suppressible by ena[+]/ena²¹⁰

(Rudrapatna et al., 2014)

Scer\GAL4^GMR.PF, bsk^UAS.cUa, hep^UAS.cUa has lethal - all die before end of pupal stage phenotype, suppressible by Styp\AvrA^UAS.Tag:MYC/Scer\GAL4^GMR.PF

(Jones et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, bsk^UAS.cUa, hep^UAS.cUa has lethal - all die before end of pupal stage phenotype, non-suppressible by Styp\AvrA^{m.UAS.Tag:MYC}/Scer\GAL4^GMR.PF

(Jones et al., 2008)

Other

Statement

Reference

Scer\GAL4^GMR.PF, Styp\AvrA^UAS.Tag:MYC, bsk^UAS.cUa, hep^UAS.cUa has viable phenotype

(Jones et al., 2008)

Scer\GAL4^GMR.PF, Styp\AvrA^UAS.Tag:MYC, bsk^UAS.cUa, hep^UAS.cUa has visible phenotype

(Jones et al., 2008)

Scer\GAL4^GMR.PF, Styp\AvrA^{m.UAS.Tag:MYC}, bsk^UAS.cUa, hep^UAS.cUa has lethal phenotype

(Jones et al., 2008)

Scer\GAL4^GMR.PF, bsk^UAS.cUa, hep^UAS.cUa has lethal - all die before end of pupal stage phenotype

(Jones et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ptc-559.1, hep^UAS.cUa has wing disc phenotype, suppressible by tsr[+]/tsr^N96A

(Rudrapatna et al., 2014)

Scer\GAL4^ptc-559.1, hep^UAS.cUa has wing disc phenotype, suppressible by ena²³/ena[+]

(Rudrapatna et al., 2014)

Scer\GAL4^ptc-559.1, hep^UAS.cUa has wing disc phenotype, suppressible by ena[+]/ena²¹⁰

(Rudrapatna et al., 2014)

Other

Statement

Reference

Scer\GAL4^GMR.PF, Styp\AvrA^UAS.Tag:MYC, bsk^UAS.cUa, hep^UAS.cUa has eye phenotype

(Jones et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of hep^UAS.cUa under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in CtBP^87De-10/+ background does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

A tsr^N96A/+ background suppresses the cell migration seen upon expression of hep^Scer\UAS.cUa under the control of Scer\GAL4^ptc-559.1.

An ena²³/+ or ena²¹⁰/+ background suppresses the cell migration seen upon expression of hep^Scer\UAS.cUa under the control of Scer\GAL4^ptc-559.1.

(Rudrapatna et al., 2014)

Co-expression of hep^Scer\UAS.cUa and bsk^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF results in pupal lethality.

(Jones et al., 2008)

Xenogenetic Interactions

Statement

Reference

Expression of Styp\AvrA^{Scer\UAS.T:Hsap\MYC} suppresses the pupal lethality seen in flies co-expressing hep^Scer\UAS.cUa and bsk^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF. The adult flies exhibit a rough eye phenotype.

Expression of Styp\AvrA^{m.Scer\UAS.T:Hsap\MYC} is unable to suppress the pupal lethality seen in flies co-expressing hep^Scer\UAS.cUa and bsk^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PF.

(Jones et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

hep^OE

(Lee et al., 2019)

hep^Scer\UAS.cUa

hep^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (12)

Report Sections

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