FlyBase Allele Report: Dmel\PRL-1[UAS.NC]

General Information

Symbol

Dmel\PRL-1^UAS.NC

Species

D. melanogaster

Name

FlyBase ID

FBal0284666

Feature type

allele

Associated gene

Dmel\PRL-1

Associated Insertion(s)

Carried in Construct

P{UAS-PRL-1.NC}

Key Links

Transgenic product class

inframe_deletion

(Pagarigan et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Pagarigan et al., 2013)

Mutagen

in vitro construct

(Pagarigan et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-PRL-1.NC}

Cytology

Description

UASt regulatory sequences drive expression of a mutant form of PRL-1 lacking its C-terminal CAAX motif.

(Pagarigan et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

PRL-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of PRL-1^Scer\UAS.NC in the dorsal compartment of the wing disc under the control of Scer\GAL4^ap-md544 has no effect on wing curvature.

Flies co-expressing PRL-1^Scer\UAS.cPa and PRL-1^Scer\UAS.NC in the dorsal compartment of the wing disc under the control of Scer\GAL4^ap-md544 do not display any wing curvature.

(Pagarigan et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PRL-1^UAS.NC, Scer\GAL4^ap-md544 is a suppressor | partially of lethal - all die before end of pupal stage phenotype of Scer\GAL4^ap-md544, Src64B^UY1332

(Pagarigan et al., 2013)

Other

Statement

Reference

PRL-1^UAS.NC, Scer\GAL4^ap-md544, Src64B^UY1332 has partially lethal - majority die phenotype

(Pagarigan et al., 2013)

PRL-1^UAS.NC, Scer\GAL4^ap-md544, Src64B^UY1332 has partially lethal - majority live phenotype

(Pagarigan et al., 2013)

PRL-1^UAS.NC, Scer\GAL4^ap-md544, Src64B^UY1332 has some die during pupal stage phenotype

(Pagarigan et al., 2013)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Expression of PRL-1^Scer\UAS.NC partially suppresses the pupal lethality seen when Src64B^UY1332 is expressed under the control of Scer\GAL4^ap-md544, enabling approximately 70% of the expected adults to eclose.

(Pagarigan et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PRL-1^Scer\UAS.NC

PRL-1^UAS.NC

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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