FB2026_02 , released June 18, 2026
Allele: Dmel\AdssF71
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General Information
Symbol
Dmel\AdssF71
Species
D. melanogaster
Name
FlyBase ID
FBal0286165
Feature type
allele
Associated gene
Dmel\Adss
Associated Insertion(s)
P{GawB}AdssF71
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Stenesen et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}AdssF71
    Cytology
    Description

    Insertion in the first exon, within the 5'UTR, 25bp upstream of the translation start site.

    (Stenesen et al., 2013)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygous males and females have an approximately 20% longer life span than sibling controls, and have reduced age-specific mortality. Heterozygous females maintain lifespan extension when exposed to both control and heterozygous males. Heterozygous males analysed in the absence of female exposure are also long lived. Heterozygotes show normal resistance to oxidative stress. Heterozygotes have an increased AMP:ATP ratio and an increased ADP:ATP ratio compared to controls.

        Dietary adenine supplementation suppresses the larval lethality of homozygotes and restores lifespan and the AMP:ATP ratio to normal in heterozygotes.

        (Stenesen et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        AdssF71 has long lived phenotype, suppressible by Scer\GAL4Adss-F71/AMPKαK57A.UAS

        (Stenesen et al., 2013)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of SNF1AK57A.Scer\UAS under the control of Scer\GAL4AdSS-F71 suppresses the increased longevity of AdSSF71/+ males and females.

        (Stenesen et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        AdssF71 is rescued by Scer\GAL4Adss-F71/AdssUAS.cSa

        (Stenesen et al., 2013)
        Comments

        Expression of AdSSScer\UAS.cSa under the control of Scer\GAL4AdSS-F71 reverts the increased longevity phenotype of AdSSF71/+ flies. The AMP:ATP and ADP:ATP ratios are also normal in the rescued flies.

        (Stenesen et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        AdSSF71
        AdssF71
        F71
        (Stenesen et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)