FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1RNAi.UAS.17.1
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General Information
Symbol
Dmel\Dscam1RNAi.UAS.17.1
Species
D. melanogaster
Name
FlyBase ID
FBal0286280
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
P{UAS-Dscam1.17.1.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Shi et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Shi et al., 2007)
Mutagen
in vitro construct
(Shi et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Dscam1.17.1.RNAi}
Cytology
Description

UAS regulates expression of a microRNA carrying a unique Dscam1 sequence derived from exon 17.1.

(Shi et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dscam1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Major neural structures of the larval CNS are unaffected by Scer\GAL4ase.neuro/Scer\GAL4elav-C155-mediated expression of DscammiRNA.Scer\UAS.17.1 or combined expression of DscammiRNA.Scer\UAS.17.1 and DscammiRNA.Scer\UAS.17.2.

      Scer\GAL4ey-OK107-mediated expression of DscammiRNA.Scer\UAS.17.1 does not disrupt the formation of the alpha/beta lobes of the adult mushroom body.

      Scer\GAL4ey-OK107-mediated co-expression of DscammiRNA.Scer\UAS.17.1 and DscammiRNA.Scer\UAS.17.2 severely disrupts the formation of the alpha/beta lobes of the adult mushroom body.

      Scer\GAL4GH146-mediated expression of DscammiRNA.Scer\UAS.17.1 in vPN neuroblast clones potently suppresses the elaboration of dendrites in the antennal lobes but only minimally disrupts their axonal arborization in the lateral horns.

      (Shi et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mushroom body "lost lobe" phenotype penetrance observed in lacek05305/lace2 transheterozygous adults is significantly decreased by the Scer\GAL4Dscam1.4.5-driven expression of Dscam1miRNA.UAS.17.1, respectively. lace2 heterozygous adults that also express Dscam1miRNA.UAS.17.1 under the control of Scer\GAL4Dscam1.4.5 do not show a mushroom body "lost lobe" phenotype.

      (Goyal et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dscam1RNAi.UAS.17.1
      Dscam1miRNA.Scer\UAS.17.1
      Dscam1miRNA.UAS.17.1
      DscammiRNA.Scer\UAS.17.1
      Name Synonyms
      Secondary FlyBase IDs
        References (4)