FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\laceU2
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General Information
Symbol
Dmel\laceU2
Species
D. melanogaster
Name
FlyBase ID
FBal0346325
Feature type
allele
Associated gene
Dmel\lace
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Goyal et al., 2019)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: M420I.

    (Hummel, 2019.6.28)

    Location and nature of lesion is a revision of data reported in FBrf0241573.

    (Hummel, 2019.6.28)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:15,503,172..15,503,172 [+]
    Nucleotide change:

    G15503172H

    Amino acid change:

    M420I | lace-PA; M420I | lace-PB

    Reported amino acid change:

    M420I

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

    (Hummel, 2019.6.28)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        laceU2 Gr21a neuron clones show axonal mistargeting defects; small/single cell clones in Or47a neurons do not show axonal mistargeting defects.

        lacek05305/laceU2 transheterozygous adults show a mushroom body "lost-lobe" phenotype in about half of cases; the overall dendrite organization seems unaffected, as indicated by microtubule polarity (nod) and compartment identity (Apc2, DenMark, etc)

        (Goyal et al., 2019)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Spt-IB2/Spt-ISH1626, laceU2/+ adults and Spt-Il(2)49Fb-4/Spt-ISH1626, laceU2/+ adults show a moderate prevalence of mushroom body defects, namely a "lost-lobe" phenotype; Spt-Il(2)49Fb-4, laceU2 double heterozygotes adults, however, rarely show mushroom body defects.

        (Goyal et al., 2019)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        laceU2
        (Goyal et al., 2019, Hummel, 2019.6.28)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)