FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Spt-Il(2)49Fb-4
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General Information
Symbol
Dmel\Spt-Il(2)49Fb-4
Species
D. melanogaster
Name
FlyBase ID
FBal0031727
Feature type
allele
Associated gene
Dmel\Spt-I
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)49Fb4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lasko and Pardue, 1988)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q90term.

(Goyal et al., 2019, Oswald et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:13,169,170..13,169,170 [+]
Nucleotide change:

C13169170T

Amino acid change:

Q90term | Spt-I-PA; Q90term | Spt-I-PB; Q90term | Spt-I-PC

Reported amino acid change:

Q90term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Oswald et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Complementation crosses of Spt-Il(2)49Fb-1, Spt-Il(2)49Fb-4 or Spt-IJO8 to each other are lethal at first instar.

      (Oswald et al., 2015)

      One copy of l(2)49Fb4 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of l(2)49Fb4 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Spt-I[+]/Spt-Il(2)49Fb-4 is an enhancer of abnormal neuroanatomy | adult stage phenotype of laceU2/lacek05305

      (Goyal et al., 2019)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Spt-Il(2)49Fb-4/Spt-ISH1626, laceU2/+ adults show a moderate prevalence of mushroom body defects, namely a "lost-lobe" phenotype; Spt-Il(2)49Fb-4, laceU2 double heterozygotes adults, however, rarely show the defects.

      (Goyal et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Spt-I49F
      (Goyal et al., 2019)
      Spt-Il(2)49Fb-4
      l(2)49Fb4
      (Oswald et al., 2015, Doheny et al., 2008)
      vr4-57
      (Renn et al., 1998)
      vr457
      (Wu and Howe, 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)