FlyBase Allele Report: Dmel\Spt-I[SH1626]

General Information

Symbol

Dmel\Spt-I^SH1626

Species

D. melanogaster

Name

FlyBase ID

FBal0143629

Feature type

allele

Associated gene

Dmel\Spt-I

Associated Insertion(s)

P{lacW}Spt-I^SH1626

Carried in Construct

Also Known As

Spt1^l(2)SH1626

Key Links

Genomic Maps

JBrowse

Allele class

hypermorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypermorphic allele - genetic evidence

(Oswald et al., 2015)

Mutagen

P-element activity

(Oh et al., 2003)

Progenitor genotype

Associated Insertion(s)

P{lacW}Spt-I^SH1626

Cytology

Description

P-element insertion in 5' UTR of Spt-I.

(Goyal et al., 2019)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,168,547..13,169,136

(Oswald et al., 2015, Sanchez, 2006, Sanchez et al., 2006, Oh et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hereditary sensory and autonomic neuropathy type 1

CEA with Spt-I^B2

(Goyal et al., 2019)

CEA with Spt-I^l(2)49Fb-4

(Goyal et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with Df(2R)vg-B)

(Oswald et al., 2015)

abnormal developmental rate (with Spt-I^JO8)

(Oswald et al., 2015)

abnormal developmental rate (with Spt-I^l(2)49Fb-1)

(Oswald et al., 2015)

abnormal developmental rate (with Spt-I^l(2)49Fb-4)

(Oswald et al., 2015)

lethal

(Sanchez et al., 2006)

lethal (with Spt-I^P1)

(Goyal et al., 2019)

lethal | recessive

(Goyal et al., 2019, Oh et al., 2003)

partially lethal - majority die (with Spt-I^B2)

(Goyal et al., 2019)

partially lethal - majority die (with Spt-I^KG06460)

(Goyal et al., 2019)

partially lethal - majority die (with Spt-I^l(2)49Fb-4)

(Goyal et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Spt-I^B2/Spt-I^SH1626 transheterozygous adults rarely show mushroom body defects.

(Goyal et al., 2019)

Eclosion time of Spt-I^SH1626/Df(2R)vg-B trans-heterozygotes is delayed by 3-5 days compared with wild-type.

(Oswald et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Spt-I^SH1626 is a non-enhancer of abnormal stress response phenotype of GLaz^Δ2

(Sanchez, 2006, Sanchez et al., 2006)

Other

Statement

Reference

Spt-I^SH1626/Spt-I^l(2)49Fb-4, lace[+]/lace^U2 has abnormal neuroanatomy | adult stage phenotype

(Goyal et al., 2019)

Spt-I^SH1626/Spt-I^B2, lace[+]/lace^U2 has abnormal neuroanatomy | adult stage phenotype

(Goyal et al., 2019)

Scer\GAL4^elav.PU, Spt-I^C129W.UAS, Spt-I^SH1626/Spt-I[+] has abnormal neuroanatomy | larval stage phenotype

(Oswald et al., 2015)

Phenotype Manifest In

Other

Statement

Reference

Spt-I^SH1626/Spt-I^l(2)49Fb-4, lace[+]/lace^U2 has lobe system of adult mushroom body phenotype

(Goyal et al., 2019)

Spt-I^SH1626/Spt-I^B2, lace[+]/lace^U2 has lobe system of adult mushroom body phenotype

(Goyal et al., 2019)

Scer\GAL4^elav.PU, Spt-I^C129W.UAS, Spt-I^SH1626/Spt-I[+] has embryonic/larval neuromuscular junction phenotype

(Oswald et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Spt-I^l(2)49Fb-4/Spt-I^SH1626, lace^U2/+ and Spt-I^B2/Spt-I^SH1626, lace^U2/+ adults show a moderate prevalence of mushroom body defects, namely a "lost-lobe" phenotype; Spt-I^l(2)49Fb-4, lace^U2 double heterozygotes adults, however, rarely show the defect.

(Goyal et al., 2019)

Introduction of heterozygous Spt-I^SH1626 in the presence of Spt-I^{C129W.Scer\UAS} and the pan-neuronal driver Scer\GAL4^elav.PU induces a 50% reduction of bouton numbers compared with wild-type.

(Oswald et al., 2015)

Spt-I^SH1626/GLaz^Δ2 transheterozygotes exhibit survival curves similar to the control GLaz^Δ2/+ or wild-type flies upon exposure to paraquat or H₂O₂.

(Sanchez et al., 2006)

Transheterozygous flies GLaz^Δ2 Spt-I^SH1626 flies are as resistant to paraquat or H₂O₂ as the controls heterozygous for either gene.

(Sanchez, 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

SPT1^l(2)SH1626

(Oswald et al., 2015)

Spt-I^SH1626

Spt-I^SH

(Goyal et al., 2019)

Spt1^l(2)SH1626

(Oswald et al., 2015, Sanchez, 2006, Sanchez et al., 2006)

dSpt1^l(2)SH1626

(Oswald et al., 2015)

l(2)SH1626^SH1626

(Sanchez, 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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