FB2026_02 , released June 18, 2026
Allele: Dmel\HtrA2V110E
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General Information
Symbol
Dmel\HtrA2V110E
Species
D. melanogaster
Name
FlyBase ID
FBal0287646
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
Also Known As
omiV110E
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Yun et al., 2008)
Mutagen
ethyl methanesulfonate
(Yacobi-Sharon et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: V110E.

(Yacobi-Sharon et al., 2013)

Contains a T-to-A transversion that results in the replacement of the valine at amino acid 110 with a glutamic acid.

(Yacobi-Sharon et al., 2013)

Nucleotide substitution: T?A.

(Yacobi-Sharon et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:14,511,078..14,511,078 [-]
Nucleotide change:

T14511078A

Reported nucleotide change:

T?A

Amino acid change:

V110E | HtrA2-PA; V110E | HtrA2-PB

Reported amino acid change:

V110E

(Yacobi-Sharon et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of HtrA2V110E/Df(3R)ED5644 mutant male flies are sterile. These flies display empty seminal vesicles and no motile sperm are observed.

      100% of HtrA2V110E/HtrA2NSO mutant male flies are sterile. These flies display empty seminal vesicles and no motile sperm are observed.

      (Yun et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HtrA2V110E
      omiV110E
      (Yacobi-Sharon et al., 2013, Yun et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)