FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dscam1RNAi.UAS.18-20
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General Information
Symbol
Dmel\Dscam1RNAi.UAS.18-20
Species
D. melanogaster
Name
FlyBase ID
FBal0287932
Feature type
allele
Associated gene
Dmel\Dscam1
Associated Insertion(s)
Carried in Construct
P{UAS-Dscam1.18-20.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Yu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Yu et al., 2009)
Mutagen
in vitro construct
(Yu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Dscam1.18-20.RNAi}
Cytology
Description

UAS regulates expression of a microRNA carrying a unique Dscam1 sequence derived from the junction between exon 18 and exon 20.

(Yu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dscam1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dscam1miRNA.UAS.18-20 under the control of Scer\GAL4elav.PU, in combination with a Dicer-2 transgene to enhance RNAi efficiency, results in locomotor defects and loss of the L-shaped structure of the adult mushroom body, compared to controls; expression under the control of Scer\GAL4elav.PU in Dscam1ΔL homozygotes also results in loss of the L-shaped structure of the adult mushroom body, compared to controls, with 100 percent penetrance; expression under the control of Scer\GAL4Pdf.PU results in a significant reduction in arborization of the adult PDF-positive ventral lateral neurons, compared to controls.

      (Zhang et al., 2019)

      Scer\GAL4ey-OK107-mediated expression of Dscam1miRNA.Scer\UAS.18-20 causes defects in larval mushroom body lobe morphology: 68% of MBs have one huge and one skinny lobe.

      Scer\GAL4ey-OK107-mediated co-expression of Dscam1miRNA.Scer\UAS.18-20 and Dscam1miRNA.Scer\UAS.19 results in 89% of MBs have one huge and one skinny lobe.

      (Yu et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Scer\GAL4tub.PU-mediated expression of Dscam1miRNA.Scer\UAS.18-20 in a Abl2/Abl4 background causes commisureless phenotypes in the ladder-like neuronal tracts in 1% of embryonic ventral ganglion segments.

      (Yu et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dscam1RNAi.UAS.18-20
      Dscam1miRNA.Scer\UAS.18-20
      Dscam1miRNA.UAS.18-20
      Name Synonyms
      Secondary FlyBase IDs
        References (3)