FB2021_01, released Feb 18, 2021

Allele: Dmel\licCA.sev.Tag:MYC

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General Information
Symbol
Dmel\licCA.sev.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0288399
Feature type
allele
Associated gene
Dmel\lic
Associated Insertion(s)
Carried in Construct
P{sev-hepCA}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Baril et al., 2009)
in vitro construct - amino acid replacement
(Baril et al., 2009)
in vitro construct - coding region fusion
(Baril et al., 2009)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{sev-hepCA}
      Cytology
      Nature of the lesion
      Statement
      Reference

      Two sev enhancer sequences upstream of a 'hsp70' promoter regulate expression of the lic[CA] in which Ser-200 and Thr-204 are replaced with Asp residues, rendering the kinase constitutively active. There is a Tag:MYC tag at the N-terminus.

      (Baril et al., 2009)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      sev
      Encoded product / tool
      lic
      Tagged with
      Tag:MYC
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      licCA.sev.T:Hsap\MYC animals display a rough eye phenotype.

      (Baril et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      licCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphS-331/alph[+]

      (Baril et al., 2009)

      licCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphGMR

      (Baril et al., 2009)

      licCA.sev.Tag:MYC has eye phenotype, non-enhanceable by alphS-331.GMR/alph[+]

      (Baril et al., 2009)
      NOT suppressed by
      Statement
      Reference

      licCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphS-331/alph[+]

      (Baril et al., 2009)

      licCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphGMR

      (Baril et al., 2009)

      licCA.sev.Tag:MYC has eye phenotype, non-suppressible by alphS-331.GMR/alph[+]

      (Baril et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      licCA.sev.T:Hsap\MYC
      licCA.sev.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)