FlyBase Allele Report: Dmel\Inx3[RNAi.UAS.WIZ]

General Information

Symbol

Dmel\Inx3^RNAi.UAS.WIZ

Species

D. melanogaster

Name

FlyBase ID

FBal0288437

Feature type

allele

Associated gene

Dmel\Inx3

Associated Insertion(s)

Carried in Construct

P{UAS-Inx3.RNAi.WIZ}

Also Known As

UASwizinx3

Key Links

Transgenic product class

RNAi_reagent

(Lehmann et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Lehmann et al., 2006)

Mutagen

in vitro construct

(Lehmann et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Inx3.RNAi.WIZ}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat (in face-to-face orientation) of a 518bp Inx3 fragment (corresponding to nucleotides 668-1186 of the cDNA).

(Lehmann et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Inx3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | embryonic stage, with Scer\GAL4^69B

(Lehmann et al., 2006)

decreased occurrence of cell division | larval stage, with Scer\GAL4^mirr-DE

(Richard et al., 2017)

decreased size | adult stage, with Scer\GAL4^c311

(Richard et al., 2017)

decreased size | adult stage, with Scer\GAL4^eya.PB

(Richard et al., 2017)

decreased size | adult stage, with Scer\GAL4^NP2631

(Richard et al., 2017)

visible | adult stage, with Scer\GAL4^c311

(Richard et al., 2017)

visible | adult stage, with Scer\GAL4^eya.PB

(Richard et al., 2017)

visible | adult stage, with Scer\GAL4^NP2631

(Richard et al., 2017)

Phenotype Manifest In

embryonic/first instar larval cuticle, with Scer\GAL4^69B

(Lehmann et al., 2006)

embryonic/first instar larval cuticle, with Scer\GAL4^prd.RG1

(Lehmann et al., 2006)

eye, with Scer\GAL4^c311

(Richard et al., 2017)

eye, with Scer\GAL4^eya.PB

(Richard et al., 2017)

eye, with Scer\GAL4^NP2631

(Richard et al., 2017)

eye disc dorsal compartment | larval stage, with Scer\GAL4^mirr-DE

(Richard et al., 2017)

ventral denticle belt, with Scer\GAL4^69B

(Lehmann et al., 2006)

ventral denticle belt, with Scer\GAL4^prd.RG1

(Lehmann et al., 2006)

Detailed Description

Statement

Reference

Expression of Inx3^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4^prd.RG1 results in cuticle defects, with holes and irregular denticle belts being seen.

Expression of Inx3^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4^69B result in embryos with a barely developed cuticle.

Most epidermal cells expressing Inx3^{dsRNA.Scer\UAS.WIZ} under the control of Scer\GAL4^69B lose their polarity in stage 6 embryos.

(Lehmann et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Inx3^RNAi.UAS.WIZ, Scer\GAL4^eya.PB has visible | adult stage phenotype, suppressible by Inx2^UAS.Tag:MYC, Scer\GAL4^eya.PB