FB2026_02 , released June 18, 2026
Allele: Dmel\Pink1G426D.UAS
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General Information
Symbol
Dmel\Pink1G426D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0288471
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{UAS-Pink1.G426D}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yun et al., 2008)
Mutagen
in vitro construct
(Yun et al., 2008)
Progenitor genotype
Pink1UAS.cCa
(Yun et al., 2008)
Carried in construct
P{UAS-Pink1.G426D}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Pink1 in which the glycine at amino acid 426 has been replaced by aspartic acid.

(Yun et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pink1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:6,685,960..6,685,960 [+]
Comment:

Analogous mutation in human PINK1 implicated in Parkinson disease 6; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

(Yun et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Yun et al., 2008)
      PINK1:p.Gly309Asp
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: PINK1_2404
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Pink1G426D.Scer\UAS under the control of Scer\GAL4GMR.PF at 18[o]C does not produce a visible eye phenotype.

      (Yun et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      HtrA2UAS.cYa, Pink1G426D.UAS, Scer\GAL4GMR.PF has visible | heat sensitive phenotype

      (Yun et al., 2008)
      Phenotype Manifest In
      Other
      Statement
      Reference

      HtrA2UAS.cYa, Pink1G426D.UAS, Scer\GAL4GMR.PF has eye | heat sensitive phenotype

      (Yun et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of HtrA2Scer\UAS.cYa and Pink1G426D.Scer\UAS under the control of Scer\GAL4GMR.PF at 18[o]C results in a small, rough eye phenotype.

      (Yun et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pink1G426D.Scer\UAS
      Pink1G426D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)