FB2026_03 , released September 17, 2026
Allele: Dmel\SclAFS.UAS.AB
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General Information
Symbol
Dmel\SclAFS.UAS.AB
Species
D. melanogaster
Name
FlyBase ID
FBal0288570
Feature type
allele
Associated gene
Dmel\SclA
Associated Insertion(s)
Carried in Construct
M{UAS-SclA-SclB.FS}
Key Links
Transgenic product class
frameshift_variant
(Magny et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
frameshift_variant
(Magny et al., 2013)
Mutagen
in vitro construct
(Magny et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-SclA-SclB.FS}
Cytology
Description

UAS regulatory sequences drive expression of the RE28911 cDNA carrying insertion mutations after the start codon of both the SclA and SclB open reading frames, resulting in a frameshift in each open reading frame. The frameshifts give rise to peptides of the same size but of a completely different sequence (MAKPATCSPPLASWPSCFSSSTSSMHM and MMRQKVCSPPSSSWPSCCSCSMPSTKAS) to wild type.

(Magny et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SclA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of M{UAS-SclA-SclB.FS} (which carries both SclAFS.Scer\UAS.AB and SclBFS.Scer\UAS.AB) under the control of Scer\GAL4Mef2.PR does not increase cardiac arrhythmicity compared to control flies.

      (Magny et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SclAFS.UAS.AB, Scer\GAL4tin.CΔ4, SclBFS.UAS.AB fails to rescue Df(2L)Scl12/Df(2L)Sclg6

      (Magny et al., 2013)

      SclAFS.UAS.AB, Scer\GAL4Mef2.PR, SclBFS.UAS.AB fails to rescue Df(2L)Scl12/Df(2L)Sclg6

      (Magny et al., 2013)
      Comments

      Expression of M{UAS-SclA-SclB.FS} (which carries both SclAFS.Scer\UAS.AB and SclBFS.Scer\UAS.AB) under the control of Scer\GAL4tin.CΔ4 fails to rescue the increased cardiac arrhythmicity seen in Df(2L)Scl12/Df(2L)Sclg6 adults.

      (Magny et al., 2013)

      Expression of M{UAS-SclA-SclB.FS} (which carries both SclAFS.Scer\UAS.AB and SclBFS.Scer\UAS.AB) under the control of Scer\GAL4Mef2.PR fails to rescue the increased cardiac arrhythmicity seen in Df(2L)Scl12/Df(2L)Sclg6 adults.

      (Magny et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SclAFS.Scer\UAS.AB
      SclAFS.UAS.AB
      Name Synonyms
      Secondary FlyBase IDs
        References (2)