FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RokS753A.S908A.UAS
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General Information
Symbol
Dmel\RokS753A.S908A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0290986
Feature type
allele
Associated gene
Dmel\Rok
Associated Insertion(s)
Carried in Construct
P{UAS-Rok.2SA}
Key Links
Transgenic product class
missense_variant
(Moon and Matsuzaki, 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Moon and Matsuzaki, 2013)
Mutagen
in vitro construct
(Moon and Matsuzaki, 2013)
Progenitor genotype
Carried in construct
P{UAS-Rok.2SA}
Cytology
Description

Amino acid replacement: S753A.

(Moon and Matsuzaki, 2013)

UASt regulatory sequences drive expression of mutated Rok coding sequences where 2 serine residues near/within the Rho-binding domain have been mutated to alanines.

(Moon and Matsuzaki, 2013)

Amino acid replacement: S908A.

(Moon and Matsuzaki, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rok
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of rokS753A.S908A.Scer\UAS under the control of Scer\GAL4GMR.PU causes much smaller, rougher eyes than in wild-type.

      (Moon and Matsuzaki, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      RokS753A.S908A.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by zip[+]/zip1

      (Moon and Matsuzaki, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A zip1 heterozygous background suppresses the small, rough eye phenotype found upon expression of rokS753A.S908A.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Moon and Matsuzaki, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RokS753A.S908A.Scer\UAS
      RokS753A.S908A.UAS
      rokS753A.S908A.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)