FlyBase Allele Report: Dmel\Wnk[ex22]

General Information

Symbol

Dmel\Wnk^ex22

Species

D. melanogaster

Name

FlyBase ID

FBal0291031

Feature type

allele

Associated gene

Dmel\Wnk

Associated Insertion(s)

P{5'EPgy2}Wnk^ex22

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Serysheva et al., 2013)

Progenitor genotype

P{EPgy2}Wnk^EY10165

(Serysheva et al., 2013)

Associated Insertion(s)

P{5'EPgy2}Wnk^ex22

Cytology

Description

Generated by imprecise excision of P{EPgy2}Wnk^EY10165 (inserted within the 5' UTR of wnk) and has a 1.4 kb deletion of genomic sequence including most of the Wnk 5' UTR to about 216 nt upstream of the start codon (note that the 5' P starting in exon 1 to a region within the w region are retained).

(Serysheva et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:21,553,336..21,554,724 [-]

Comment:

~1.4 kb deletion resulting from the imprecise excision of P{EPgy2}Wnk^EY10165, which removes most of the 5' UTR of Wnk and ends in exon 3 (junction sequence between w sequences in residual P element and exon 3 is tgaacaccacgcctacACCACCAGCTGCCAGCAAAA).

(Serysheva et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Yarikipati et al., 2023, Serysheva et al., 2013)

lethal (with Df(3L)ED4978)

(Yarikipati et al., 2023, Serysheva et al., 2013)

lethal (with Wnk^AA16.DsRed+)

(Yarikipati et al., 2023)

lethal (with Wnk^MB06499)

(Yarikipati et al., 2023, Serysheva et al., 2013)

viable (with Wnk^AA16)

(Yarikipati et al., 2023)

viable (with Wnk^AA21)

(Yarikipati et al., 2023)

Phenotype Manifest In

posterior wing margin | somatic clone

(Serysheva et al., 2013)

rhabdomere of eye photoreceptor cell

(Yarikipati et al., 2023)

wing margin bristle | somatic clone

(Serysheva et al., 2013)

Detailed Description

Statement

Reference

Mutant clones in the wing result in loss of wing margin and missing margin bristles. However, no typical planar cell polarity phenotypes are detected.

(Serysheva et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Wnk[+]/Wnk^ex22 is a non-suppressor of abnormal planar polarity phenotype of dsh^sev.PU

(Serysheva et al., 2013)

Phenotype Manifest In