FlyBase Allele Report: Dmel\Wnk[AA16.DsRed+]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Wnk^AA16.DsRed+

General Information

Symbol

Dmel\Wnk^AA16.DsRed+

Species

D. melanogaster

Name

FlyBase ID

FBal0397344

Feature type

allele

Associated gene

Associated Insertion(s)

TI{TI}Wnk^AA16.DsRed+

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Yarikipati et al., 2023)

Mutagen

(Yarikipati et al., 2023)

gene targeting by homologous recombination

(Yarikipati et al., 2023)

Progenitor genotype

Associated Insertion(s)

TI{TI}Wnk^AA16.DsRed+

Cytology

Description

The FRSV motif of the endogenous Wnk locus has been mutated to AASV (the mutation also introduces a silent NheI site). A sequence cassette encoding a Disc\RFP^{DsRed(T1).3xP3.cHa} marker flanked by termini from the Tni\piggyBac transposable element has also been inserted. The encoded protein includes 20 residues from Wnk after the AA mutation, and then 8 novel amino acids from the inserted sequence cassette, followed by a stop codon.

(Yarikipati et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)ED4978)

(Yarikipati et al., 2023)

lethal (with Wnk^ex22)

(Yarikipati et al., 2023)

lethal (with Wnk^MB06499)

(Yarikipati et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Yarikipati et al., 2023)

(Yarikipati et al., 2023)

Rescued by

Df(3L)ED4978/Wnk^AA16.DsRed+ is rescued by Wnk^{ΔMid.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Df(3L)ED4978/Wnk^AA16.DsRed+ is rescued by Wnk^{αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is rescued by Wnk^{ΔCC2.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is rescued by Wnk^{ΔMid.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is rescued by Wnk^{αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is rescued by Wnk^{ΔCC.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is rescued by Wnk^{ΔCC2.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is rescued by Wnk^{ΔMid.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is rescued by Wnk^{αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Partially rescued by

Df(3L)ED4978/Wnk^AA16.DsRed+ is partially rescued by Wnk^{ΔAI.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is partially rescued by Wnk^{ΔAI.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is partially rescued by Wnk^{ΔCC.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is partially rescued by Wnk^{ΔNT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is partially rescued by Wnk^{ΔAI.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Not rescued by

Df(3L)ED4978/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCC.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Df(3L)ED4978/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCC1.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Df(3L)ED4978/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCC2.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Df(3L)ED4978/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Df(3L)ED4978/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔNT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCC1.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^ex22/Wnk^AA16.DsRed+ is not rescued by Wnk^{ΔCT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is not rescued by Wnk^{ΔCC1.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is not rescued by Wnk^{ΔCT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Wnk^AA16.DsRed+/Wnk^MB06499 is not rescued by Wnk^{ΔNT.αTub84B.Tag:HA}

(Yarikipati et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

99480

w^*; TI{TI}Wnk^AA16.DsRed+/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Wnk^AA16.DsRed+

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections