FlyBase Allele Report: Dmel\Hmgcr[HMC03053]

General Information

Symbol

Dmel\Hmgcr^HMC03053

Species

D. melanogaster

Name

FlyBase ID

FBal0292265

Feature type

allele

Associated gene

Dmel\Hmgcr

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03053}

Also Known As

UAS-Hmgcr RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03053}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03053

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of myopathy

CEA

(Al-Sabri et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

decreased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

decreased occurrence of cell division, with Scer\GAL4^NP5130

(Miao et al., 2026)

decreased rate of adult locomotory behavior, with Scer\GAL4^Mhc.F3-580

(Al-Sabri et al., 2022)

decreased rate of movement | adult stage, with Scer\GAL4^Mhc.F3-580

(Al-Sabri et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Hmgcr^HMC03053 under the control of Scer\GAL4^Cg.PA leads to swollen mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Acc^HMS01230, Hmgcr^HMC03053, Scer\GAL4^{VP16.nanos.UTR} has decreased cell number | oogenesis phenotype

(Amartuvshin et al., 2025)

Phenotype Manifest In

Other

Statement

Reference

Acc^HMS01230, Hmgcr^HMC03053, Scer\GAL4^{VP16.nanos.UTR} has female germline cyst phenotype

(Amartuvshin et al., 2025)

Acc^HMS01230, Hmgcr^HMC03053, Scer\GAL4^{VP16.nanos.UTR} has female fusome phenotype

(Amartuvshin et al., 2025)

Acc^HMS01230, Hmgcr^HMC03053, Scer\GAL4^{VP16.nanos.UTR} has female germline stem cell | decreased number phenotype

(Amartuvshin et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

50652

y¹ v¹; P{TRiP.HMC03053}attP40

NIG-Fly

HMC03053

y¹ v¹; P{TRiP.HMC03053}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hmgcr^HMC03053

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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