FlyBase Allele Report: Dmel\scra[HMC03587]

General Information

Symbol

Dmel\scra^HMC03587

Species

D. melanogaster

Name

FlyBase ID

FBal0292722

Feature type

allele

Associated gene

Dmel\scra

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03587}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03587}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03587

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Chen et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Adult flies expressing scra^HMC03587 under the control of Scer\GAL4^Dot.PK do not display any nephrocyte functional defects (measured by uptake assays) and their adult lifespan is also comparable to controls.

(Fu et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^elav.PLu, scra^HMC03587 has decreased rate of larval locomotory behavior phenotype, non-enhanceable by Mtl^JF03037, Scer\GAL4^elav.PLu

(Huynh et al., 2025)

Scer\GAL4^VGlut1-OK371, scra^HMC03587 has decreased rate of larval locomotory behavior phenotype, non-enhanceable by Mtl^JF03037, Scer\GAL4^VGlut1-OK371

(Huynh et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^elav.PLu, scra^HMC03587 has decreased rate of larval locomotory behavior phenotype, non-suppressible by Mtl^JF03037, Scer\GAL4^elav.PLu

(Huynh et al., 2025)

Scer\GAL4^VGlut1-OK371, scra^HMC03587 has decreased rate of larval locomotory behavior phenotype, non-suppressible by Mtl^JF03037, Scer\GAL4^VGlut1-OK371

(Huynh et al., 2025)

NOT Enhancer of

Statement

Reference

scra^HMC03587, Scer\GAL4^elav.PLu is a non-enhancer of decreased rate of larval locomotory behavior phenotype of Mtl^JF03037, Scer\GAL4^elav.PLu

(Huynh et al., 2025)

Suppressor of

Statement

Reference

scra^HMC03587, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

scra^HMC03587, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

NOT Suppressor of

Statement

Reference

scra^HMC03587, Scer\GAL4^elav.PLu is a non-suppressor of decreased rate of larval locomotory behavior phenotype of Mtl^JF03037, Scer\GAL4^elav.PLu

(Huynh et al., 2025)

Phenotype Manifest In

Suppressor of

Statement

Reference

scra^HMC03587, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

scra^HMC03587, Scer\GAL4^repo.PU is a suppressor of larval brain neuropil glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

53358

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03587}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scra^HMC03587

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections