FlyBase Allele Report: Dmel\Fhos[HMJ21037]

General Information

Symbol

Dmel\Fhos^HMJ21037

Species

D. melanogaster

Name

FlyBase ID

FBal0292870

Feature type

allele

Associated gene

Dmel\Fhos

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ21037}

Also Known As

Fhos RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMJ21037}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ21037

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates synucleinopathy

modeled by Hsap\SNCA^QUAS.cOa

(Ordonez et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Fhos^HMJ21037 under the control of Scer\GAL4^elav-C155 has no significant effect on adult locomotor (in negative geotaxis assays), on the number of rod-shaped actin-rich inclusions or on the mitochondria size in the adult brain, as compared to controls.

(Ordonez et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of decreased cell number | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of abnormal size | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of adult brain phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of neuron | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of dopaminergic medulla neuron phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of filamentous actin | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Scer\GAL4^elav-C155/Fhos^HMJ21037 is a suppressor of mitochondrion | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Ordonez et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The additional expression of Fhos^HMJ21037 under the control of Scer\GAL4^elav-C155 partially suppresses the adult locomotor activity defects, the adult brain vacuolization, the decreased number of neurons (including TH-immunoreactive dopaminergic neurons), the increased number of rod-shaped actin-rich inclusions and the increased mitochondria size in the adult brain resulting from the expression of Hsap\SNCA^{Ncra\QUAS.cOa} under the control of Ncra\QF^QF2.nSyb.

(Ordonez et al., 2018)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

51391

y¹ v¹; P{TRiP.HMJ21037}attP40

NIG-Fly

HMJ21037