FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\α-Cat3
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General Information
Symbol
Dmel\α-Cat3
Species
D. melanogaster
Name
FlyBase ID
FBal0294014
Feature type
allele
Associated gene
Dmel\α-Cat
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Imprecise excision of P{EP}GE30561 removes a 2083bp region extending to both sides of the insertion site. This deletes the first exon of α-Cat, including the translation start site and much of the intergenic region between α-Cat and the predicted gene CG32230.

    (Sarpal et al., 2012)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    3L:23,338,005..23,340,088 [-]
    Comment:

    A 2083bp deletion resulting from the imprecise excision of P{EP}GE30561 removes the first exon of alpha-Cat, including the translation start site, and much of the intergenic region between alpha-Cat and ND-MLRQ. (Reported R4 coordinates converted to R6)c

    (Sarpal et al., 2012)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The cuticle of α-Cat3 mutant embryos shows severe defects in the head skeleton, which result from a failure in head involution. The failure of head involution leaves a large anterior opening in the epidermis through which internal organs are expelled, and the epidermis/cuticle shrinks as a result of muscle contractions. The ventral and dorsal cuticle appear normal and no obvious defects are observed in other embryonic tissues.

        (Sarpal et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        α-Cat3 is rescued by Scer\GAL4Act.PU/Scer\GAL4da.G32/α-CatΔCTD.UAS.Tag:HA

        (Sarpal et al., 2012)
        Comments

        Expression of α-CatΔCTD.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4da.G32 and Scer\GAL4Act.PU rescues the lethality seen in α-Cat3 mutant embryos.

        (Sarpal et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        α-Cat3
        (Sarpal et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)