FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\CAGQ76.UAS.EGFP,Tag:FLAG
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General Information
Symbol
Zzzz\CAGQ76.UAS.EGFP,Tag:FLAG
Species
a. artificial
Name
FlyBase ID
FBal0294221
Feature type
allele
Associated gene
Zzzz\CAG
Associated Insertion(s)
Carried in Construct
P{UAS-EGFP.polyQ76.FLAG}
Transgenic product class
trinucleotide_repeat_expansion
(Wong et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(Wong et al., 2008)
Mutagen
in vitro construct
(Wong et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-EGFP.polyQ76.FLAG}
Cytology
Description

UASt regulatory sequences drive expression of an expanded polyQ repeat (Q76) that is tagged at the N-terminal end with EGFP and at the C-terminal end with Tag:FLAG.

(Wong et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Zzzz\CAG
Tagged with
EGFP
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is exacerbated by Cul1GD9650
      (Chen et al., 2019)
      is exacerbated by FipoQNIG.2010R
      (Chen et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Wong et al., 2008)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Zzzz\CAGQ76.UAS.EGFP,Tag:FLAG under the control of Scer\GAL4GMR.PU induces loss of eye pigmentation.

      (Chen et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The eye pigmentation loss induced by the expression of Zzzz\CAGQ76.UAS.EGFP,Tag:FLAG under the control of Scer\GAL4GMR.PU are aggravated by the co-expression of either Cul1GD9650 or FipoQNIG.2010R to the point of even leading to necrotic scars.

      (Chen et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Avic\GFPEGFP.Scer\UAS.T:Zzzz\CAG-76,T:Zzzz\FLAG
      Zzzz\CAGQ76.T:Avic\GFP-EGFP,T:Zzzz\FLAG
      Zzzz\CAGQ76.UAS.EGFP,Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0294220
      References (4)