FB2026_02 , released June 18, 2026
Allele: Dmel\SmnHMC03832
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General Information
Symbol
Dmel\SmnHMC03832
Species
D. melanogaster
Name
FlyBase ID
FBal0294391
Feature type
allele
Associated gene
Dmel\Smn
Associated Insertion(s)
Carried in Construct
P{TRiP.HMC03832}
Also Known As
UAS-Smn-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMC03832}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMC03832
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  spinal muscular atrophy
      is ameliorated by Hsap\TGS1UAS.cMa
      (Chen et al., 2022)
      is ameliorated by Tgs1UASp.EGFP
      (Chen et al., 2022)
      model of  childhood spinal muscular atrophy
      is ameliorated by Tgs1GD14932
      (Maccallini et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larvae expressing SmnHMC03832 under the control of Scer\GAL4elav-C155 larvae show decreased locomotion and their neuromuscular junctions are abnormal, with fewer boutons, compared to controls.

      (Li et al., 2020)

      Expression of SmnHMC03832 under the control of Scer\GAL4GMR.PU leads to mild defects in eye morphology.

      (Mirra et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Phenotype Manifest In
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of SmnHMC03832 does not modify the mild eye defects seen in flies expressing Hsap\FUSMM.Scer\UAS.T:Zzzz\FLAG or Hsap\FUSScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PU.

      (Mirra et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Supplemental Dataset_S01.

      (Yan and Perrimon, 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SmnHMC03832
      Name Synonyms
      Secondary FlyBase IDs
        References (11)