FlyBase Allele Report: Dmel\ImpL2[HMC03863]

General Information

Symbol

Dmel\ImpL2^HMC03863

Species

D. melanogaster

Name

FlyBase ID

FBal0294422

Feature type

allele

Associated gene

Dmel\ImpL2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03863}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03863}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03863

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates high grade glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor | partially of neoplasia | adult stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

NOT Suppressor of

Statement

Reference

ImpL2^HMC03863, Scer\GAL4^apolpp.PU is a non-suppressor of decreased cell size | larval stage phenotype of Pgam1^HMC04818, Scer\GAL4^apolpp.PU

(Rodríguez-Vázquez et al., 2024)

Phenotype Manifest In

Suppressor of

Statement

Reference

ImpL2^HMC03863, Scer\GAL4^apolpp.PU is a suppressor of hypodermal muscle of A1-7 | larval stage phenotype of Pgam1^HMC04818, Scer\GAL4^apolpp.PU

(Rodríguez-Vázquez et al., 2024)

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor of adult neuromuscular junction phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor of presynaptic active zone | adult stage | decreased number phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor | partially of CNS glial cell | increased number | adult stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

ImpL2^HMC03863, Scer\GAL4^repo is a suppressor | partially of adult brain phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Jarabo et al., 2021)

NOT Suppressor of

Statement

Reference

ImpL2^HMC03863, Scer\GAL4^apolpp.PU is a non-suppressor of embryonic/larval fat body | larval stage phenotype of Pgam1^HMC04818, Scer\GAL4^apolpp.PU

(Rodríguez-Vázquez et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

55855

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03863}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ImpL2^HMC03863

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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