FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fw42
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General Information
Symbol
Dmel\fw42
Species
D. melanogaster
Name
FlyBase ID
FBal0295047
Feature type
allele
Associated gene
Dmel\fw
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Chin and Mlodzik, 2013)
Mutagen
ethyl methanesulfonate
(Chin and Mlodzik, 2013)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Chin and Mlodzik, 2013)

Amino acid replacement: W689term.

(Chin and Mlodzik, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,995,488..11,995,488 [-]
Nucleotide change:

G11995488A

Reported nucleotide change:

G?A

Amino acid change:

W689term | fw-PA; W270term | fw-PB; W689term | fw-PC

Reported amino acid change:

W689term

Comment:

Nonsense mutation (TGG to TGA) at Trp codon.

(Chin and Mlodzik, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous males show planar cell polarity defects in the eye, including altered ommatidial rotation and occasional symmetric ommatidia. Mild photoreceptor cell loss is also seen. Strong planar cell polarity defects are also seen in the notum, with misoriented bristles and cell hairs. Bristles in the notum are often thicker and shorter than normal. Wing hairs show misorientation in several regions, consistently in the area posterior to vein L5.

      Homozygous clones in the eye show planar cell polarity defects.

      (Chin and Mlodzik, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      fw42 is an enhancer of abnormal planar polarity phenotype of stanfrz3

      (Chin and Mlodzik, 2013)

      fw[+]/fw42 is an enhancer of abnormal planar polarity phenotype of Scer\GAL4nub.PU, VangUAS.cWa

      (Chin and Mlodzik, 2013)
      Suppressor of
      Statement
      Reference

      fw[+]/fw42 is a suppressor of abnormal planar polarity phenotype of fzhs.sev

      (Chin and Mlodzik, 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      fw42 is an enhancer of wing phenotype of stanfrz3

      (Chin and Mlodzik, 2013)

      fw42 is an enhancer of ommatidium phenotype of stanfrz3

      (Chin and Mlodzik, 2013)

      fw42 is an enhancer of adult thorax phenotype of stanfrz3

      (Chin and Mlodzik, 2013)

      fw[+]/fw42 is an enhancer of wing hair phenotype of Scer\GAL4nub.PU, VangUAS.cWa

      (Chin and Mlodzik, 2013)
      Suppressor of
      Statement
      Reference

      fw42 is a suppressor of ommatidium phenotype of fzhs.sev

      (Chin and Mlodzik, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      fw42/+ partially suppresses the symmetrical ommatidia phenotype caused by fzhs.sev. fw42/Y also partially suppresses the symmetrical ommatidia phenotype caused by fzhs.sev and in this case photoreceptor cell loss is also seen.

      fw42/+ enhances the wing planar polarity phenotype caused by expression of VangScer\UAS.cWa under the control of Scer\GAL4nub.PU.

      fw42 enhances the planar cell polarity defects seen in stanfrz3 flies in all tissues examined (eyes, wings and thorax).

      (Chin and Mlodzik, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      fw1

      (Chin and Mlodzik, 2013)
      Rescued by

      fw42 is rescued by fwTub.EGFP

      (Chin and Mlodzik, 2013)
      Partially rescued by

      fw42 is partially rescued by fwΔN.Tub.EGFP

      (Chin and Mlodzik, 2013)
      Not rescued by

      fw42 is not rescued by fwΔCCP2.Tub.EGFP

      (Chin and Mlodzik, 2013)
      Comments

      fwΔN.tub.T:Avic\GFP-EGFP rescues all planar cell polarity defects of fw42, but fails to rescue the bristle shape defects and "furrowed" eye phenotype.

      (Chin and Mlodzik, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      42-m9
      (Chin and Mlodzik, 2013)
      fw42
      (Chin and Mlodzik, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)