FlyBase Allele Report: Dmel\lig[R185C.UAS.UTR]

General Information

Symbol

Dmel\lig^{R185C.UAS.UTR}

Species

D. melanogaster

Name

FlyBase ID

FBal0295160

Feature type

allele

Associated gene

Dmel\lig

Associated Insertion(s)

Carried in Construct

M{UAS-lig.R185C.UTR}

Key Links

Transgenic product class

missense_variant

(Baumgartner et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Baumgartner et al., 2013)

Mutagen

in vitro construct

(Baumgartner et al., 2013)

Progenitor genotype

Carried in construct

M{UAS-lig.R185C.UTR}

Cytology

Description

UAS regulates expression of the lig coding sequence containing a R185C substitution (relative to release 5.45 sequence, but published as wild type in FBrf0155809), and including parts of the 5' and 3' UTRs.

(Baumgartner et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

lig

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | nutrition conditional, with Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Phenotype Manifest In

eye | nutrition conditional, with Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Detailed Description

Statement

Reference

Scer\GAL4^ey.PH-mediated expression strongly reduces eye size and ommatidial number in a diet-dependent manner - the eye phenotype is partially rescued in flies grown on 25% yeast-containing food.

(Baumgartner et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has abnormal size phenotype, suppressible | partially by Diap1^EP3723, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has abnormal size phenotype, suppressible | partially by CycE^UAS.cUa, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has abnormal size phenotype, suppressible | partially by Diap1^EP3723/CycE^UAS.cUa, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has eye phenotype, suppressible | partially by Diap1^EP3723, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has eye phenotype, suppressible | partially by CycE^UAS.cUa, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Scer\GAL4^ey.PH, lig^{R185C.UAS.UTR} has eye phenotype, suppressible | partially by Diap1^EP3723/CycE^UAS.cUa, Scer\GAL4^ey.PH

(Baumgartner et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The small eye phenotype of Scer\GAL4^ey.PH lig^{R185C.Scer\UAS.UTR} flies is partially rescued by co-expression of th^EP3723 or CycE^Scer\UAS.cUa, and rescued further by co-expression of both th^EP3723 or CycE^Scer\UAS.cUa.

(Baumgartner et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lig^{R185C.Scer\UAS.UTR}

lig^{R185C.UAS.UTR}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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