FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Septin22
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General Information
Symbol
Dmel\Septin22
Species
D. melanogaster
Name
FlyBase ID
FBal0295819
Feature type
allele
Associated gene
Dmel\Septin2
Associated Insertion(s)
Carried in Construct
Also Known As
Sep22
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(O'Neill and Clark, 2013)
Progenitor genotype
P{EPgy2}Septin2EY05856
(O'Neill and Clark, 2013)
Cytology
Description

Excision of P{EPgy2}Sep2EY05856 resulting in deletion of the 5' two-thirds of Sep2, corresponding to Release 5 coordinates 3R:16412437..16414076 .

(O'Neill and Clark, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:20,586,715..20,588,354 [-]
Comment:

1640 bp deleiton resulting from the imprecise excision of P{EPgy2}Septin2EY05856 (removes 3R:16412437..16414076 in R5 coordinates).

(O'Neill and Clark, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous adults lay eggs with a shorter anterior-posterior axis than wild type.

      Sibling crosses between homozygotes either produce no eggs, or eggs that don't hatch. Crosses between homozygous females and wild type males result in a few viable eggs, but eggs are not produced or don't hatch in the majority of cases. Crosses between homozygous males and wild type females result in a viable eggs in 20% of cases, and unhatched eggs in the other 80%.

      About half of Sep21/Sep22 transheterozygotes die as pharates.

      Only 54% of Sep22 egg chambers have the wild type number of nurse cell nuclei (15); the remaining chambers have either more or fewer, ranging from 3 to 57.

      (O'Neill and Clark, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sep21/Sep22, Sep51/Sep52 animals arrest as prepupae. Wandering third instars of this genotype completely lack imaginal discs.

      (O'Neill and Clark, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sep22
      (Stjepić et al., 2024, Gabbert et al., 2023, Deb and Hasan, 2019, O'Neill and Clark, 2016, O'Neill and Clark, 2013)
      Septin22
      (Gabbert et al., 2023)
      ΔdSEPT22
      (Deb and Hasan, 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)