FB2026_02 , released June 18, 2026
Allele: Dmel\Septin52
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General Information
Symbol
Dmel\Septin52
Species
D. melanogaster
Name
FlyBase ID
FBal0295822
Feature type
allele
Associated gene
Dmel\Septin5
Associated Insertion(s)
Carried in Construct
Also Known As
Sep52
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(O'Neill and Clark, 2013)
Progenitor genotype
P{EP}Septin5G6155
(O'Neill and Clark, 2013)
Cytology
Description

Excision of P{EP}Sep5G6155 resulting in deletion of almost all of Sep5, corresponding to Release 5 coordinates 2R:3847816..3849373 .

(O'Neill and Clark, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:7,960,311..7,961,868 [-]
Comment:

1558 bp deletion resulting from the imprecise excision of P{EP}Septin5G6155 removes most of Septin5 (covers 2R:3847816..3849373 in Release 5 coordinates).

(O'Neill and Clark, 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes do not appear to have any defects.

      (O'Neill and Clark, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sep21/Sep22, Sep51/Sep52 animals arrest as prepupae. Wandering third instars of this genotype completely lack imaginal discs.

      A low percentage of Sep52, Sep21 larval neuroblasts have tetraploid nuclei, compared to 0% in wild type.

      (O'Neill and Clark, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sep52
      (Stjepić et al., 2024, O'Neill and Clark, 2016, O'Neill and Clark, 2013)
      Septin52
      Name Synonyms
      Secondary FlyBase IDs
        References (3)