FB2020_06, released Dec 22, 2020

Allele: Dmel\fand1

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General Information
Symbol
Dmel\fand1
Species
D. melanogaster
Name
FlyBase ID
FBal0295911
Feature type
allele
Associated gene
Dmel\fand
Associated Insertion(s)
Carried in Construct
Genomic Maps
Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Guilgur et al., 2014)
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    2R:13,594,985..13,594,985 [+]
    Nucleotide change:

    C13594985T

    Amino acid change:

    A401V | fand-PA

    Reported amino acid change:

    A401V

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Guilgur et al., 2014)
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
         
        Progenitor genotype
        Cytology
        Nature of the lesion
        Statement
        Reference

        Amino acid replacement: A401V.

        (Guilgur et al., 2014)
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Syncytial blastoderm nuclear divisions are normal in embryos derived from homozygous female germline clones, but cortical nuclei fail to elongate and become mislocalised during blastoderm cellularisation.

        (Guilgur et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        fandP218

        (Sauerwald et al., 2017)

        fandH124

        (Sauerwald et al., 2017)
        Rescued by

        fand1 is rescued by fand+tGa

        (Guilgur et al., 2014)
        Comments

        The fand1 allele fails to complement both fandP218 and fandH124 alleles.

        (Sauerwald et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        fand1
        (Sauerwald et al., 2017, Guilgur et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)