FB2026_02 , released June 18, 2026
Allele: Dmel\fand2
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General Information
Symbol
Dmel\fand2
Species
D. melanogaster
Name
FlyBase ID
FBal0295912
Feature type
allele
Associated gene
Dmel\fand
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Guilgur et al., 2014)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    18 nucleotide deletion, removing 6 amino acid residues (codons 355 to 360) in tetratricopeptide repeat domain VI.

    (Guilgur et al., 2014)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    deletion
    2R:13,594,846..13,594,863 [+]
    Comment:

    18bp deletion that removes amino acid residues 355-360.

    (Guilgur et al., 2014)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Syncytial blastoderm nuclear divisions are normal in embryos derived from homozygous female germline clones, but cortical nuclei fail to elongate and become mislocalised during blastoderm cellularisation.

        (Guilgur et al., 2014)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        fandH124

        (Sauerwald et al., 2017)

        fandP218

        (Sauerwald et al., 2017)
        Rescued by

        fand2 is rescued by fand+tGa

        (Guilgur et al., 2014)
        Comments

        The fand2 allele fails to complement both fandP218 and fandH124 alleles.

        (Sauerwald et al., 2017)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        fand2
        (Sauerwald et al., 2017, Guilgur et al., 2014)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)