FB2026_02 , released June 18, 2026
Allele: Dmel\fzyUAS.cKa
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General Information
Symbol
Dmel\fzyUAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kuang
FlyBase ID
FBal0295948
Feature type
allele
Associated gene
Dmel\fzy
Associated Insertion(s)
Carried in Construct
P{UAS-fzy.K}
Key Links
Transgenic product class
wild_type
(Kuang et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kuang et al., 2014)
Mutagen
in vitro construct
(Kuang et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-fzy.K}
Cytology
Description

UAS regulatory sequences drive expression of wild type fzy.

(Kuang et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fzy
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of fzyScer\UAS.cKa suppresses the neuroblast loss seen in larval brains expressing CG7033GD5201 under the control of Scer\GAL4wor.PA. However, these surviving neuroblasts display phenotypes indicative of mitotic catastrophe including multinucleation and enlargement of cell diameter.

      Expression of fzyScer\UAS.cKa under the control of Scer\GAL4wor.PA suppresses the neuroblast loss seen in Su(var)2054/Su(var)2055 mutant larval brains. However, these surviving neuroblasts display phenotypes indicative of mitotic catastrophe including multinucleation and enlargement of cell diameter.

      Expression of fzyScer\UAS.cKa under the control of Scer\GAL4wor.PA partially suppresses the neuroblast loss seen in Fen1EY12786 mutant larval brains. However, these surviving neuroblasts display phenotypes indicative of mitotic catastrophe including multinucleation and enlargement of cell diameter.

      Expression of fzyScer\UAS.cKa partially suppresses the neuroblast loss seen in larval brains expressing p53259H.GUS under the control of Scer\GAL4wor.PA.

      (Kuang et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/fzyUAS.cKa rescues fzy4

      (Kuang et al., 2014)
      Comments

      Expression of fzyScer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroepithelial cell clones in the larval optic lobe.

      Expression of fzyScer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroblast clones in the larval brain.

      (Kuang et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fzyScer\UAS.cKa
      fzyUAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kuang
      Secondary FlyBase IDs
        References (1)