FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\aubHR-E721A
Open Close
General Information
Symbol
Dmel\aubHR-E721A
Species
D. melanogaster
Name
FlyBase ID
FBal0296115
Feature type
allele
Associated gene
Dmel\aub
Associated Insertion(s)
TI{TI}aubHR-E721A
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Gell and Reenan, 2013)
Progenitor genotype
Associated Insertion(s)
TI{TI}aubHR-E721A
Cytology
Description

Mutation in the endogenous aub locus on the SD-LosArenos chromosome, changing the catalytic glutamic acid required for RNA slicer activity into an alanine. A loxP cassette containing a w+* marker has also been introduced downstream of the 3' end of the aub gene.

(Gell and Reenan, 2013)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      aubHR-E721A/aub[+] is an enhancer of abnormal meiotic cell cycle phenotype of RanGAPSd

      (Gell and Reenan, 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The segregation distortion seen in males carrying the SD-LosArenos Dp(2;2)RanGAPSD chromosome variant is enhanced (the k[[c]] value, or proportion of Dp(2;2)RanGAPSD-bearing progeny as the fraction of total progeny (corrected for viability), is significantly increased) if the males are also carrying a single copy of aubHR-E721A.

      (Gell and Reenan, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      aubHR-E721A
      (Gell and Reenan, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)