FlyBase Allele Report: Dmel\SERCA[UAS.Tag:MYC]

General Information

Symbol

Dmel\SERCA^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0296373

Feature type

allele

Associated gene

Dmel\SERCA

Associated Insertion(s)

Carried in Construct

P{UAS-Ca-P60.MYC}

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Bi et al., 2014)

in vitro construct - coding region fusion

(Bi et al., 2014)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-Ca-P60.MYC}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of SERCA tagged at the N-terminal end with Tag:MYC.

(Bi et al., 2014)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

SERCA

Tagged with

Tag:MYC

epitope tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by trp^P365

(Huang et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

SERCA^UAS.Tag:MYC/Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy | dominant | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

SERCA^UAS.Tag:MYC/Scer\GAL4^GMR.PF is a suppressor of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of trp^P365

(Huang et al., 2016)

SERCA^UAS.Tag:MYC, Scer\GAL4^ppl.PP is a suppressor | partially of adult fat body phenotype of Scer\GAL4^ppl.PP, Seipin^null

(Bi et al., 2014)

SERCA^UAS.Tag:MYC, Scer\GAL4^ppl.PP is a suppressor | partially of lipid droplet phenotype of Scer\GAL4^ppl.PP, Seipin^null

(Bi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of SERCA^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^GMR.PF suppresses retinal degeneration (loss of rhabdomeres from photoreceptors) in 5 day old trp^P365/+ flies.

(Huang et al., 2016)

Expression of Ca-P60A^{Scer\UAS.T:Hsap\MYC} partially rescues the reduction in lipid droplet size seen in Seipin^null mutant fat body cells. The reduction in ionomycin-evoked cytosolic calcium release is also partially rescued.

(Bi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ca-P60A^{Scer\UAS.T:Hsap\MYC}

SERCA^{Scer\UAS.T:Hsap\MYC}

SERCA^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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