FlyBase Allele Report: Dmel\Vps60[d08528-f02548]

General Information

Symbol

Dmel\Vps60^{d08528-f02548}

Species

D. melanogaster

Name

FlyBase ID

FBal0296662

Feature type

allele

Associated gene

Dmel\Vps60

Associated Insertion(s)

Carried in Construct

Also Known As

Df(3L)d08528-f02548

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Berns et al., 2014)

Mutagen

FLPase

(Berns et al., 2014)

Progenitor genotype

P{XP}Eip74EF^d08528

(Berns et al., 2014)

PBac{WH}f02548

(Berns et al., 2014)

Cytology

Description

Recombination between the progenitor insertions results in a small deletion that uncovers the entire ORF of Vps60 but of no other gene.

(Berns et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:17,619,425..17,621,571 [-]

Comment:

Recombination between the two progenitor insertions, PBac{WH}f02548 and P{XP}Eip74EF^d08528 removes Vps60 and no other genes.

(Berns et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Berns et al., 2014)

lethal - all die before end of larval stage | cold sensitive

(Bäumers et al., 2019)

lethal - all die before end of P-stage

(Bäumers et al., 2019)

Phenotype Manifest In

epithelium | somatic clone

(Berns et al., 2014)

female germline cyst | somatic clone

(Berns et al., 2014)

stalk follicle cell | somatic clone

(Berns et al., 2014)

Detailed Description

Statement

Reference

Germaria that consist mostly of Vps60^{d08528-f02548} cells show misalignment of cysts and elongated stalks.

(Berns et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Vps60^{d08528-f02548} has epithelium | somatic clone phenotype, suppressible by Scer\GAL4^NP1624/N^KK102890

(Berns et al., 2014)

Vps60^{d08528-f02548} has stalk follicle cell | somatic clone phenotype, suppressible by Scer\GAL4^NP1624/N^KK102890

(Berns et al., 2014)

Vps60^{d08528-f02548} has female germline cyst | somatic clone phenotype, suppressible by Scer\GAL4^NP1624/N^KK102890

(Berns et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^tj-NP1624-mediated expression of N^KK102890 prevents the formation of elongated stalks and the disorganization of germaria seen in germaria are composed mostly of Vps60^{d08528-f02548} cells.

(Berns et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Df(3L)d08528-f02548

(Bäumers et al., 2019, Berns et al., 2014)

Vps60^{d08528-f02548}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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