FB2026_02 , released June 18, 2026
Allele: Dmel\otkUASp.GFP
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General Information
Symbol
Dmel\otkUASp.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0297439
Feature type
allele
Associated gene
Dmel\otk
Associated Insertion(s)
Carried in Construct
P{UASp-otk-GFP}
Key Links
Transgenic product class
wild_type
(Linnemannstöns et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Linnemannstöns et al., 2014)
Mutagen
in vitro construct
(Linnemannstöns et al., 2014)
Progenitor genotype
Carried in construct
P{UASp-otk-GFP}
Cytology
Description

UASp regulatory sequences drive expression of otk coding sequences tagged with GFP.

(Linnemannstöns et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
otk
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of otkScer\UAS.T:Avic\GFP under the control of the ubiquitous driver Scer\GAL4da.G32 has no effect on viability and fertility, with the corresponding ovaries being indistinguishable from wild-type ovaries. Overexpression of two copies of otkScer\UAS.T:Avic\GFP leads to flies that are viable but female sterile. All stages of oogenesis are present in these ovaries, but mature eggs are never deposited by these females due to malformation and obstruction of the oviduct.

      (Linnemannstöns et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4da.G32/otkUASp.GFP rescues Df(2R)D72

      (Linnemannstöns et al., 2014)
      Comments

      Expression of otkScer\UAS.T:Avic\GFP under the control of the ubiquitous driver Scer\GAL4da.G32 rescues the Df(2R)D72 mutant male sterile phenotype.

      (Linnemannstöns et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      otkScer\UAS.T:Avic\GFP
      otkUASp.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)