FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NLazL130R.UAS
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General Information
Symbol
Dmel\NLazL130R.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0297989
Feature type
allele
Associated gene
Dmel\NLaz
Associated Insertion(s)
Carried in Construct
M{UAS-NLaz.L130R}
Key Links
Transgenic product class
missense_variant
(Ruiz et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ruiz et al., 2014)
Mutagen
in vitro construct
(Ruiz et al., 2014)
Progenitor genotype
Carried in construct
M{UAS-NLaz.L130R}
Cytology
Description

UASt regulatory sequences drive expression of NLaz containing the amino acid replacement L130R.

(Ruiz et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
NLaz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      30 day old flies expressing NLazL130R.Scer\UAS under the control of Scer\GAL4da.PU show a 13.5% decrease in median survival and a 8.9% decrease in maximal survival compared to controls after exposure to paraquat.

      (Ruiz et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4da.PU/NLazL130R.UAS partially rescues NLazNW5

      (Ruiz et al., 2014)
      Comments

      Expression of NLazL130R.Scer\UAS under the control of Scer\GAL4da.PU partially rescues survival of 3 day old NLazNW5 flies exposed to paraquat or to starvation-dessication stress, but is unable to rescue the reduced longevity of NLazNW5 flies seen in the absence of added stress.

      (Ruiz et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NLazL130R.Scer\UAS
      NLazL130R.UAS
      NLazL130R
      (Ruiz et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)