FB2026_02 , released June 18, 2026
Allele: Dmel\SynjUAS.Tag:HA
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General Information
Symbol
Dmel\SynjUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0298821
Feature type
allele
Associated gene
Dmel\Synj
Associated Insertion(s)
Carried in Construct
P{UAS-Synj.HA}
Also Known As
UAS-synjwt
Key Links
Transgenic product class
wild_type
(Chen et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen et al., 2014)
Mutagen
in vitro construct
(Chen et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Synj.HA}
Cytology
Description

UAS regulatory sequences drive expression of the Synj coding region tagged with Tag:HA.

(Chen et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Synj
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      SynjUAS.Tag:HA/Scer\GAL4nSyb.PS is a suppressor | partially of NMJ bouton phenotype of mnb1

      (Chen et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of SynjScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4nSyb.PS suppresses the increase in bouton size in mnb1 mutant NMJs, but does not suppress the reduction in bouton number.

      Expression of SynjScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4nSyb.PS significantly rescues the excitatory postsynaptic potential (EPSP) amplitude defects seen in response to high frequency stimulation seen in mnb1 mutant larvae. However these larvae also show a slightly faster rundown than controls after prolonged stimulation. The miniature EPSP (mEPSP) and endocytosis defects are also rescued.

      (Chen et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      SynjUAS.Tag:HA/Scer\GAL4nSyb.PS rescues Synj2/Synj1

      (Geng et al., 2016)
      Comments

      Expression of SynjScer\UAS.T:Ivir\HA1 under the Scer\GAL4nSyb.PS driver rescues the active synaptic vesicle endocytosis defects as well as the abnormal rapid rundown of evoked excitatory postsynaptic potential amplitude observed in the Synj1/Synj2 mutant larvae upon high frequency stimulation for a prolonged period of time.

      (Geng et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SynjScer\UAS.T:Ivir\HA1
      SynjUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)