FB2026_02 , released June 18, 2026
Allele: Dmel\foxoGD4348
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General Information
Symbol
Dmel\foxoGD4348
Species
D. melanogaster
Name
FlyBase ID
FBal0298980
Feature type
allele
Associated gene
Dmel\foxo
Associated Insertion(s)
Carried in Construct
P{GD4348}
Also Known As
UAS-FOXO RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Wong et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Wong et al., 2014)
Mutagen
in vitro construct
(Wong et al., 2014)
Progenitor genotype
Carried in construct
P{GD4348}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Wong et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD4348
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Tas et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of foxoGD4348 under the control of either Scer\GAL4GMR58E02 or Scer\GAL4Fer2.2359 leads to a significant and progressive decrease in the number of dopaminergic PAM neurons in the adult brain, as compared to controls; adulthood-only expression under the control of Scer\GAL4Fer2.2359 (and Gal80[ts], for the temporal control of expression) also leads to a significant decrease in the number of dopaminergic PAM neurons, albeit less severe.

      (Tas et al., 2018)

      RNAi knockdown of foxo, through expression of foxoGD4348 in the posterior compartment of the wing disc, under the control of either Scer\GAL4en.PU or Scer\GAL4hh.PU, does not affect levels of cell death.

      (Wong et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      There is a significant reduction in chromosome instability tolerance induced by mad2GD16427 expression, when foxoGD4348 is expressed in imaginal wing discs under the control of Scer\GAL4en.PU or Scer\GAL4hh.PU. There is also a concomitant significant increase in cell death in these double mutants. Consistent with high levels of cell death and consequent loss of tissue, adult wings show notching when JNK signalling is reduced in a chromosome instability background (through expression of mad2GD16427).

      (Wong et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      foxoGD4348
      Name Synonyms
      Secondary FlyBase IDs
        References (6)