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General Information
Symbol
Dmel\foxoGD4348
Species
D. melanogaster
Name
FlyBase ID
FBal0298980
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of foxoGD4348 under the control of either Scer\GAL4GMR58E02 or Scer\GAL4Fer2.2359 leads to a significant and progressive decrease in the number of dopaminergic PAM neurons in the adult brain, as compared to controls; adulthood-only expression under the control of Scer\GAL4Fer2.2359 (and Gal80[ts], for the temporal control of expression) also leads to a significant decrease in the number of dopaminergic PAM neurons, albeit less severe.

RNAi knockdown of foxo, through expression of foxoGD4348 in the posterior compartment of the wing disc, under the control of either Scer\GAL4en.PU or Scer\GAL4hh.PU, does not affect levels of cell death.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

There is a significant reduction in chromosome instability tolerance induced by mad2GD16427 expression, when foxoGD4348 is expressed in imaginal wing discs under the control of Scer\GAL4en.PU or Scer\GAL4hh.PU. There is also a concomitant significant increase in cell death in these double mutants. Consistent with high levels of cell death and consequent loss of tissue, adult wings show notching when JNK signalling is reduced in a chromosome instability background (through expression of mad2GD16427).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
foxoGD4348
Name Synonyms
Secondary FlyBase IDs
    References (4)