FlyBase Allele Report: Dmel\Pen[ΔIBB.UASp]

General Information

Symbol

Dmel\Pen^ΔIBB.UASp

Species

D. melanogaster

Name

FlyBase ID

FBal0300958

Feature type

allele

Associated gene

Dmel\Pen

Associated Insertion(s)

Carried in Construct

P{UASp-Pen.ΔIBB}

Key Links

Transgenic product class

inframe_deletion

(Gorjanacz et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Gorjanacz et al., 2006)

Mutagen

in vitro construct

(Gorjanacz et al., 2006)

Progenitor genotype

Carried in construct

P{UASp-Pen.ΔIBB}

Cytology

Description

UASp regulatory sequences drive expression of a mutated Pen cDNA sequence which lacks the IBB domain (deletion of amino acid residues 25-90).

(Gorjanacz et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Pen

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-enhancer of increased mortality during development | maternal effect phenotype of Fs(2)Ket^RP13, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-enhancer of increased mortality during development | maternal effect phenotype of Fs(2)Ket^RX13, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-enhancer of increased mortality during development | maternal effect phenotype of Fs(2)Ket^c02473, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-enhancer of increased mortality during development | maternal effect phenotype of Fs(2)Ket^e02657, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-enhancer of increased mortality during development | maternal effect phenotype of Fs(2)Ket^e03750, Pen^D14

(Virágh et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-suppressor of increased mortality during development | maternal effect phenotype of Fs(2)Ket^RP13, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-suppressor of increased mortality during development | maternal effect phenotype of Fs(2)Ket^RX13, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-suppressor of increased mortality during development | maternal effect phenotype of Fs(2)Ket^c02473, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-suppressor of increased mortality during development | maternal effect phenotype of Fs(2)Ket^e02657, Pen^D14

(Virágh et al., 2012)

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp is a non-suppressor of increased mortality during development | maternal effect phenotype of Fs(2)Ket^e03750, Pen^D14

(Virágh et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^{VP16.nanos.UTR}/Pen^ΔIBB.UASp partially rescues Pen^D14

(Gorjanacz et al., 2006)

Fails to rescue

Scer\GAL4^c747/Pen^ΔIBB.UASp fails to rescue Pen^mbmB

(Serway et al., 2020)

Comments

Expression of Pen^{ΔIBB.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in Pen^D14 females restores egg laying to an average of 12.0 eggs/day. However, 86% of the eggs have abnormally fused dorsal appendages, approximately 10% are shorter than normal and none of the eggs hatch. 27% of ring canals in the ovary are fully occluded by actin.

(Gorjanacz et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pen^{ΔIBB.Scer\UAS.P\T}

Pen^ΔIBB.UASp

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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