FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AcnS641A.S731A.Tag:MYC
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General Information
Symbol
Dmel\AcnS641A.S731A.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0301149
Feature type
allele
Associated gene
Dmel\Acn
Associated Insertion(s)
Carried in Construct
PBac{AcnP-Myc-Acn.S641A.S731A}
Key Links
Transgenic product class
missense_variant
(Nandi et al., 2014)
polypeptide_post_translational_processing_variant
(Nandi et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Nandi et al., 2014)
polypeptide_post_translational_processing_variant
(Nandi et al., 2014)
Mutagen
in vitro construct
(Nandi et al., 2014)
Progenitor genotype
Carried in construct
PBac{AcnP-Myc-Acn.S641A.S731A}
Cytology
Description

4kb genomic fragment that encompasses the Acn gene. The coding sequence has been mutated to carry the S641A and S731A amino acid replacements (elimination of both potential Akt1 phosphorylation sites) and is tagged at the N-terminal end with Tag:MYC.

(Nandi et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Acn
Encoded product / tool
Acn
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Basal levels of autophagy are unaltered in Acnt.S641A.S731A flies.

      Starvation conditions lead to an increase in autophagy in Acnt.S641A.S731A mutants.

      Flies carrying one copy of Acnt.S641A.S731A do not survive significantly longer in the absence of food than wild-type flies do.

      Flies carrying one copy of Acnt.S641A.S731A do not exhibit a difference in longevity compared to control flies.

      (Nandi et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      AcnS641A.S731A.Tag:MYC rescues Acn27/Acn1

      (Nandi et al., 2014)
      Comments

      The presence of Acnt.S641A.S731A rescues both the lethality and endocytic trafficking defects of Acn27/Acn1 mutant flies. These rescued flies do not display externally visible phenotypes.

      (Nandi et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AcnS641A.S731A.Tag:MYC
      Acnt.S641A.S731A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)