FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\AcnS641D.S731D.Tag:MYC
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General Information
Symbol
Dmel\AcnS641D.S731D.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0301150
Feature type
allele
Associated gene
Dmel\Acn
Associated Insertion(s)
Carried in Construct
PBac{AcnP-Myc-Acn.S641D.S731D}
Key Links
Transgenic product class
missense_variant
(Nandi et al., 2014)
polypeptide_post_translational_processing_variant
(Nandi et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Nandi et al., 2014)
polypeptide_post_translational_processing_variant
(Nandi et al., 2014)
Mutagen
in vitro construct
(Nandi et al., 2014)
Progenitor genotype
Carried in construct
PBac{AcnP-Myc-Acn.S641D.S731D}
Cytology
Description

4kb genomic fragment that encompasses the Acn gene. The coding sequence has been mutated to carry the S641D and S731D amino acid replacements (phosphomimetic mutations at both potential Akt1 phosphorylation sites) and is tagged at the N-terminal end with Tag:MYC.

(Nandi et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Acn
Encoded product / tool
Acn
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye discs expressing Acnt.S641D.S731D display exhibit an increased number of autophagosomes.

      Fat bodies of fed Acnt.S641D.S731D larvae exhibit significantly enhanced basal autophagy at early and late stages of the autophagy pathway.

      Starvation conditions lead to an increase in autophagy in Acnt.S641D.S731D mutants.

      Flies carrying one copy of Acnt.S641D.S731D survive significantly longer in the absence of food than wild-type flies.

      Flies carrying one copy of Acnt.S641D.S731D exhibit greater longevity than control flies.

      (Nandi et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The build up of aggregates seen in two week-old Hsap\HTTQ93.ex1p.Scer\UAS-expressing flies is reduced by the presence of one copy of Acnt.S641D.S731D.

      (Nandi et al., 2014)
      Complementation and Rescue Data
      Rescues

      AcnS641D.S731D.Tag:MYC rescues Acn27/Acn1

      (Nandi et al., 2014)
      Comments

      The presence of Acnt.S641A.S731A rescues both the lethality and endocytic trafficking defects of Acn27/Acn1 mutant flies. These rescued flies do not display externally visible phenotypes.

      (Nandi et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AcnS641D.S731D.Tag:MYC
      Acnt.S641D.S731D
      Name Synonyms
      Secondary FlyBase IDs
        References (1)